Fig. 4From: Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registryDynamics of medication management. Mean effects over the time course of the pandemic, calculated by means of generalized mixed-effect models, are depicted by a red continuous line. 95% confidence intervals of the effect are depicted as shaded red area. The given p values originate from an analysis of devianceBack to article page