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Table 1 Baseline (pre-randomization) characteristics comparisons

From: The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing

Parameters All patients
n = 374
Not ready for weaning group
(Recovery phase)
n = 139
ZERO CPAP tolerance failure group
(Weaning phase)
n = 101
SBT failure
Group
(Weaning phase)
n = 41
SNR Group
(Recovery phase)
n = 93
p value
Age, years 63 ± 13 62 ± 13 63 ± 14 63 ± 13 65 ± 13 0.326
Male – n (%) 242 (65) 95 (69) 58 (59) 30 (75) 59 (65) 0.212
BMI, Kg/m2 – median [IQR] 27.8 [24.2–32.1] 28.9 [25.1–34.5] 27.0 [23.5–30.2] 25.9 [23.3–31.2] 28.1 [24.9–32.0] 0.010
RASS −1.37 ± 1.65 −1.59 ± 1.78 −1.44 ± 1.67 −1.22 ± 1.60 −1.01 ± 1.38 0.062
Postoperative – n (%) 74 (20) 17 (12) 19 (19) 7 (17) 31 (33) 0.001
Prognostic scores
Day 0 SOFA score 6.50 ± 3.35 6.60 ± 3.19 5.73 ± 3.06 5.42 ± 2.70 7.55 ± 3.80  < 0.001†§
Charlson Comorbidity Index 4.41 ± 3.13 4.11 ± 3.16 4.31 ± 2.87 5.24 ± 3.74 4.64 ± 3.02 0.216
APACHE III score 77 ± 30 83 ± 27 74 ± 28 71 ± 30 73 ± 35 0.023*
Mode of ventilation at enrollment
Pressure ACV – n (%) 19 (5) 10 (7) 3 (3) 0 (0) 6 (7) 0.189
Volume ACV – n (%) 22 (6) 9 (7) 8 (8) 0 (0) 5 (5) 0.327
PSV – n (%) 325 (87) 118 (85) 88 (85) 40 (98) 79 (85) 0.179
Other (including PAV +) – n (%) 10 (3) 2 (1) 4 (4) 1 (2) 3 (3) 0.665
First intubation to enrollment, days 5.9 ± 5.0 6.6 ± 4.8 6.8 ± 5.9 5.2 ± 4.6 4.5 ± 4.1 NA
Gas exchange
PaO2/FiO2 236 ± 81 218 ± 103 260 ± 101 242 ± 70 286 ± 102  < 0.001*
PaCO2 41.2 ± 8.0 42.3 ± 8.1 41.1 ± 8.9 40.4 ± 6.7 39.8 ± 7.1 0.132
Respiratory parameters
FiO2, % 38 ± 8 43 ± 9 36 ± 6 37 ± 6 34 ± 6  < 0.001*
Pressure support, cmH2O 10.3 ± 3.4 11.1 ± 3.5 10.9 ± 3.2 9.7 ± 3.0 8.7 ± 2.9  < 0.001*†
PEEP, cmH2O 7.8 ± 2.5 9.7 ± 2.3 7.0 ± 1.7 6.6 ± 1.4 6.1 ± 1.6  < 0.001*
Vt, mL 516 ± 155 547 ± 171 461 ± 130 514 ± 128 528 ± 151  < 0.001
RR, breaths/min 20.9 ± 6.8 21.7 ± 7.2 23.1 ± 7.3 21.0 ± 6.1 17.4 ± 4.4  < 0.001*†§
VE, L/min 10.3 ± 3.3 11.2 ± 3.3 10.1 ± 3.2 10.4 ± 3.2 9.0 ± 3.1  < 0.001*
  1. Data presented as mean ± standard deviation unless otherwise stated
  2. Pairwise comparisons between groups by Tukey Honest Significant Difference Test where p = 0.05 was taken as a threshold for these post-hoc comparisons:
  3. ACV: assist control ventilation, APACHE: acute physiology and chronic health evaluation, BMI: body mass index, CPAP: continuous positive airway pressure, SNR: screened and non-randomized, FiO2: fraction of inspired oxygen, IQR: interquartile range, MV: mechanical ventilation, NA: not available, PAV + : proportional assist ventilation, PEEP: positive end-expiratory pressure, PSV: pressure support ventilation, RASS: Richmond agitation and sedation scale, RR: respiratory rate, SBT: spontaneous breathing trial, SOFA: sequential organ failure assessment, VE: minute ventilation, Vt: tidal volume
  4. *Difference (p < 0.05) between Not ready for weaning group vs. SNR group
  5. Difference (p < 0.05) between ZERO CPAP tolerance failure group vs. SNR group
  6. §Difference (p < 0.05) between SBT failure group vs. SNR group