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Table 1 Patient characteristics at enrolment

From: Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades

General characteristics

Overall

(n = 6086)

% DR

2011–2021

(n = 1243)

2000–2010

(n = 4843)

p value**

Age (year)

63 (59–65)

(95.9)

63 (59–65)

63 (58–67)

0.52

Male (n, %)

3552 (58.3)

(87.1)

2837 (58.6)

715 (57.5)

0.52

SAPS II (points)

53 (45–59)

(39.5)

55 (45–60)

53 (40–57)

0.34

SOFA (points)

10 (7–11)

(22.5)

10 (7–11)

11 (9–14)

0.10

APACHE (points)

20 (19–26)

(22.5)

24 (19–27)

19 (12–21)

0.12

Data regarding respiratory support

 

(70.9)

   

Totally controlled ventilatory support (n; %)

2658 (56.6)

 

1955 (56.2)

703 (57.9)

0.29

PCV (n; %)

150 (3.2)

 

128 (3.6)

22 (1.8)

 

VCV (n; %)

2428 (51.7)

 

1747 (50.2)

681 (56.1)

 

APRV (n; %)

80 (1.7)

 

80 (2.3)

0 (0–0)

 

Partially controlled ventilatory support (n; %)

1503 (32.0)

 

1161 (33.4)

342 (28.1)

0.05

ACV (n; %)

1256 (26.7)

 

990 (28.4)

266 (21.9)

 

PSV (n; %)

247 (5.3)

 

171 (4.9)

76 (6.2)

 

Spontaneously breathing (n; %)

530 (10.1)

 

362 (10.4)

168 (13.8)

0.001

VT (mL/Kg ideal body weight)

7 (7–8)

(70.9)

7 (6–8)

8 (7–9)

0.03

Type of patients*

 

(91.9)

   

Sepsis/septic shock (%)

3546 (50.6)

 

2823 (50.5)

723 (51.2)

0.63

Haemorrhagic/hypovolemic shock (%)

344 (4.9)

 

252 (13.9)

92 (6.5)

< 0.0001

Trauma (%)

120 (1.7)

 

101 (1.8)

19 (1.3)

0.25

ARDS/pneumonia (%)

1741 (24.8)

 

1428 (25.5)

313 (22.2)

0.009

Postoperative optimization (%)

1005 (14.3)

 

780 (13.9)

225 (15.9)

0.06

Cardiogenic (%)

193 (2.7)

 

160 (2.8)

33 (2.3)

0.31

Other (%)

53 (0.7)

 

47 (2.8)

6 (0.5)

0.12

  1. Data presented as median (25th–75th IQR), as appropriate; % DR, percentage of studies reporting the data indicated, SAPS, simplified acute physiology score; SOFA, sequential organ failure assessment; APACHE, Acute Physiologic Assessment and Chronic Health Evaluation; PCV, pressure-controlled ventilation; VCV, volume-controlled ventilation; APRV, Airway pressure release ventilation; ACV, assisted-controlled ventilation; PSV, pressure support ventilation; ARDS, acute respiratory distress syndrome; VT, tidal volume. *The overall number of patients stratified by typology is more significant as compared to the overall number of patients included in the studies because of partial overlapping classification (i.e., sepsis/septic shock and ARDS/pneumonia); **p value refers to the comparison between 2000–2010 versus 2011–2021 subgroups