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Table 2 Ventilatory and hemodynamic changes between tidal volume-guided ventilation and driving pressure-guided ventilation

From: Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the Acute Respiratory Distress Syndrome

 

PBW-guided ventilation

ΔP-guided ventilation

p

FiO2, %

50 [40–60]

50 [40–60]

1.00

PEEP, cm H2O

10 [8–12]

10 [8–12]

1.00

Tidal volume, mL/kg PBW

6.1 [5.9–6.2]

7.7 [6.2–8.7]

 < 0.001

Respiratory rate, breaths/min

29 [26–32]

21 [16–28]

 < 0.001

Minute ventilation, L/min

11.3 [9.7–12.7]

10.2 [8.9–11.6]

 < 0.001

EtCO2, mm Hg

30 [27–36]

30 [27–37]

0.16

Plateau pressure, cm H2O

22 [19–25]

24 [22–26]

 < 0.001

Auto-PEEP, cm H2O

1 [1–1.25]

1 [0–1]

0.002

Driving pressure, cm H2O

10 [9–13]

13 [12–14]

 < 0.001

Airways resistance, cm H2O/L/s

13 [9–16]

13 [9–16]

0.71

Respiratory system compliance, mL/cm H2O

38 [27–48]

40 [27–48]

0.15

Mechanical power, J/min

31.5 [28–35.7]

28.8 [24.6–32.6]

 < 0.001

Elastic power, J/min

18.4 [15.1–20.9]

16.6 [13.7–20.9]

 < 0.001

Resistive power, J/min

14.1 [9.9–16.6]

12.0 [9.7–13.8]

 < 0.001

NorMP, J/min/kg

0.50 [0.43–0.58]

0.46 [0.36–0.55]

 < 0.001

SpO2, %

96 [93–97]

95 [94–97]

0.72

PaO2/FiO2

126 [107–157]

135 [104–172]

0.005

PaCO2, cm H2O

42 [37–48]

42 [35–48]

0.07

Alveolar dead space, %

26 [16–34]

29 [15–34]

0.07

Ventilatory ratio

1.97 [1.66–2.46]

1.77 [1.40–2.27]

 < 0.001

Heart rate, beats/min

71 [64–85]

72 [63–88]

0.34

Mean arterial pressure, mm Hg

80 [72–88]

81 [71–88]

0.61

Lactate, mmol/L

1.4 [1–2.2]

1.5 [1–2.1]

0.70

Transthoracic echocardiography (n = 24)

   

Cardiac output, L/min

4.2 [3.6–4.8]

4.1 [3.8–5.1]

0.97

RV surface, cm2

15 [13–17]

15 [13–17]

0.76

RV/LV ratio

0.60 [0.50–0.61]

0.60 [0.51–0.68]

0.74

Tricuspid S’ wave, cm/s

15.5 [11.3–17.5]

14.2 [11.1–17]

0.02

TAPSE, mm

19 [17–22]

20 [17–23]

0.10

PAPs, mm Hg

38 [31–46]

38 [29–42]

0.28

Inferior vena cava, mm

22 [16–24]

21 [18–23]

0.73

  1. PBW predicted body weight, ΔP driving pressure, FiO2 inspired fraction of oxygen, PEEP positive end expiratory pressure, EtCO2 end-tidal CO2, NorMP mechanical power normalized to predicted body weight, RV right ventricle, LV left ventricle. TAPSE tricuspid annular plane systolic excursion, PAPs systolic pulmonary arterial pressure