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Table 3 Site of infections and isolated pathogens in the 128 targeted antimicrobial therapies underwent ECPA program

From: Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill patients

Site of infectionsa

Pneumonia

50 (38.2%)

Bloodstream infection

34 (26.0%)

Complicated intra-abdominal infection

29 (22.1%)

Complicated urinary tract infection

9 (6.9%)

Bone and joint infection

4 (3.1%)

Necrotizing soft tissue infection

2 (1.5%)

Meningitis

2 (1.5%)

Catheter-related bloodstream infection

1 (0.7%)

Isolated pathogensb

Gram-positive (9)

 Staphylococcus aureus

7 (5.1%)

 Enterococcus faecium

2 (1.4%)

Gram-negative (115)

 Pseudomonas aeruginosa

31 (22.6%)

 Escherichia coli

24 (17.5%)

 Klebsiella pneumoniae

22 (16.1%)

 Proteus mirabilis

7 (5.1%)

 Enterobacter cloacae complex

7 (5.1%)

 Klebsiella aerogenes

6 (4.3%)

 Serratia marcescens

4 (2.9%)

 Klebsiella oxytoca

2 (1.4%)

 Klebsiella variicola

2 (1.4%)

 Morganella morganii

2 (1.4%)

 Acinetobacter baumannii

2 (1.4%)

 Proteus vulgaris

1 (0.7%)

 Citrobacter koseri

1 (0.7%)

 Hafnia alvei

1 (0.7%)

 Pantoea spp

1 (0.7%)

 Acinetobacter pittii

1 (0.7%)

 Stenotrophomonas maltophilia

1 (0.7%)

Anaerobes (1)

 Bacteroides faecis

1 (0.7%)

Atypical (4)

 Legionella pneumophila

4 (2.9%)

Fungi (8)

 Candida albicans

5 (3.7%)

 Candida glabrata

1 (0.7%)

 Aspergillus fumigatus

1 (0.7%)

 Aspergillus terreus

1 (0.7%)

Virus

 CMV reactivation

1 (0.7%)

  1. aOverall, 131 different site of infections were identified for the 128 targeted antimicrobial therapies
  2. bOverall, 137 different pathogens were identified for the 128 targeted antimicrobial therapies
  3. CMV cytomegalovirus
  4. Data are presented as n (%)