Skip to main content

Table 4 Safety outcomes

From: Early versus delayed enteral nutrition in mechanically ventilated patients with circulatory shock: a nested cohort analysis of an international multicenter, pragmatic clinical trial

Outcomes

All (n = 626)

Early EN (Within 48 h from ICU admission) (n = 526)

Delayed EN (> 48 h from ICU admission) (n = 100)

p

Enteral feeding intolerance, n (%)

Overall EFI

161 (25)

High gastric residuals

45 (7.2)

39 (7.4)

6 (6.0)

0.62

Increased abdominal girth or abdominal distention

29 (4.6)

23 (4.4)

6 (6.0)

0.48

Vomiting/emesis

68 (10.9)

55 (10.5)

13 (13.0)

0.45

Diarrhea

15 (2.4)

12 (2.3)

3 (3.0)

0.67

Subjective discomfort

4 (0.6)

4 (0.8)

0 (0.0)

0.38

Labs from first 12 ICU days

Highest creatinine (n), mean ± SD; [range] µmol/L

(624) 124.0 ± 113.8 [17.8–1589.2]

(524) 123.6 ± 116.8 [17.8–1589.2]

(100) 125.9 ± 97.2 [29.2–531.5]

0.56

Highest urea/bun (n), mean ± SD; [range] mmol/L

(614) 13.3 ± 8.0 [1.8–50.7]

(515) 13.3 ± 8.3 [2.4–50.7]

(99) 13.2 ± 6.8 [1.8–32.8]

0.44

Lowest phosphate (n), mean ± SD; [range] mmol/L

(608) 1.1 ± 0.3 [0.5–2.9]

(508) 1.1 ± 0.3 [0.5–2.5]

(100) 1.1 ± 0.4 [0.6–2.9]

0.89

Highest triglycerides (n), mean ± SD; [range] mmol/L

(166) 2.3 ± 1.7 [0.3–16.8]

(140) 2.3 ± 1.8 [0.3–16.8]

(26) 2.0 ± 1.1 [0.3–5.5]

0.58

  1. Numeric variables are represented as “n” and percentage (%); mean and standard deviation (±) and [ranges]; EFI enteral feeding intolerance, EN enteral nutrition