One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial

Table 3 One-year functional outcomes and quality of life, by subphenotype

Variables	Both groups* n = 147	Focal ARDS n = 60	Non-focal ARDS n = 87	p values^‡
Health-related quality of life: SF-36 (normalised score)
Physical functioning, median [IQR]	37 [21–47]	37 [21–47]	34 [21–48]	0.80
Physical component summary, median [IQR]	37 [31–46]	39 [34–45]	36 [30–47]	0.47
Mental health, median [IQR]	44 [38–52]	44 [35–52]	44 [38–51]	0.38
Mental component summary, median [IQR]	41 [34–49]	39 [32–48]	41 [36–51]	0.20
Mental health symptoms: HAD
Anxiety subscale, median [IQR]	6 [3–10]	7 [4–10]	6 [3–9]	0.09
Patients with anxiety, n (%)	60 (41%)	27 (45%)	33 (38%)	0.44
Depression subscale, median [IQR]	6 [3–9]	6 [4–9]	6 [3–9]	0.23
Patients with depression, n (%)	51 (35%)	22 (37%)	29 (33%)	0.75
Effect of fatigue on quality of life: MFIS
Physical functioning, median [IQR]	25 [18–30]	24 [15–29]	25 [18–30]	0.42
Cognitive functioning, median [IQR]	18 [10–25]	18 [10–26]	17 [10–25]	0.51
Psychosocial functioning, median [IQR]	5 [2–6]	5 [2–7]	5 [2–6]	0.68
MFIS component summary, median [IQR]	48 [33–59]	46 [35–61]	48 [32–58]	0.97
Patients with fatigue, n (%)	91 (62%)	34 (57%)	57 (66%)	0.43

Explanation of scoring: SF-36 normalised score (median = 50; SD = 10; range 0–100, higher score is better); HAD anxiety and depression subscale scores (range 0–21, lower score is better); presence of anxiety or depression was defined by a HAD subscale over 7; MFIS component summary (range 0–84, lower is better), MFIS subscale scores: physical (range 0–36), cognitive (range 0–40), psychosocial (range 0–8), fatigue was defined by a MFIS over 38
ARDS, acute respiratory distress syndrome; HAD, Hospital Anxiety and Depression Scale; IQR, interquartile range 25–75%; MFIS, Modified Fatigue Impact Scale; SF-36, Short Form 36 instrument
*Both groups reported patients in the per-protocol analysis
^‡p values are reported between focal and non-focal ARDS (p value < 0.05 are in bold type)

ISSN: 1364-8535