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Table 2 Cox model result of the multivariate analysis for early and late mortality

From: One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial

Predictors

Early mortality

Late mortality

Hazard ratio*

p value

Hazard ratio*

p value

Non-focal ARDS

4.40 [1.93–10.01]

 < 0.001

2.79 [0.81–9.63]

0.106

Age

1.04 [1.02–1.07]

 < 0.001

1.03 [0.99–1.07]

0.126

Males

0.85 [0.45–1.60]

0.618

0.82 [0.25–2.74]

0.751

Haematological cancers

2.27 [0.95–5.43]

0.064

1.73 [0.17–17.70]

0.642

Non-haematological cancers

2.09 [0.95–4.57]

0.066

1.48 [0.39–5.68]

0.566

COPD

1.33 [0.55–3.25]

0.525

2.30 [0.54–9.84]

0.263

McCabe

1.11 [0.71–1.73]

0.645

3.56 [1.45–8.72]

0.005

BMI

0.99 [0.94–1.05]

0.789

0.93 [0.84–1.04]

0.213

SAPS II (without age)†

1.02 [1.00–1.04]

0.047

1.02 [0.98–1.07]

0.357

PaO2/FiO2

1.00 [1.00–1.01]

0.586

0.99 [0.98–1.00]

0.065

Plateau pressure

1.12 [0.91–1.37]

0.285

0.86 [0.59–1.25]

0.426

PEEP

0.90 [0.74–1.10]

0.305

1.07 [0.72–1.58]

0.740

Driving pressure

0.91 [0.74–1.11]

0.360

1.16 [0.80–1.68]

0.426

Shock

1.24 [0.67–2.27]

0.493

1.55 [0.48–5.06]

0.466

Mechanical ventilation over 48 h

2.08 [0.61–7.09]

0.243

0.71 [0.15–3.28]

0.659

Steroid

1.13 [0.63–2.03]

0.689

1.66 [0.54–5.12]

0.381

Renal replacement therapy

2.42 [1.40–4.20]

0.002

0.29 [0.06–1.46]

0.133

Intervention arm in LIVE study$

0.65 [0.38–1.11]

0.115

1.66 [0.56–4.96]

0.362

  1. Early and late mortality were defined as mortality in the first 90 days and mortality between day 90 and 1 year, respectively (p values < 0.05 are in bold type)
  2. ARDS, acute respiratory distress syndrome; FiO2, fraction of inspired oxygen; CI95%, 95% confidence interval; PaO2, partial pressure of oxygen in arterial blood; SAPS II, Simplified Acute Physiology Score II
  3. *Results are reported as hazard ratio [CI95%]
  4. †SAPS II predictors include SAPS II without age due to the presence of the age already in the model
  5. $Intervention arm is explained in the LIVE study report