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Table 1 Characteristic and clinical baseline patient data

From: One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial

Variables

Both groups*

n = 360

Focal ARDS

n = 124

Non-focal ARDS

n = 236

P value‡

Baseline patient data

Age, years, mean [SD]

61 [15]

61 [15]

62 [15]

0.301

Males, n (%)

266 (74%)

101 (81%)

165 (70%)

0.018

Female, n (%)

94 (26%)

23 (19%)

71 (30%)

0.018

COPD, n (%)

32 (9%)

16 (13%)

16 (7%)

0.052

Chronic renal failure, n (%)

6 (2%)

1 (1%)

5 (2%)

0.355

Non-haematological cancers, n (%)

41 (11%)

13 (10%)

28 (12%)

0.695

Haematological cancers, n (%)

14 (4%)

3 (2%)

11 (5%)

0.296

Diabetes, n (%)

41 (11%)

14 (11%)

27 (11%)

0.966

Arterial hypertension, n (%)

75 (21%)

26 (21%)

49 (21%)

0.964

Smoking, n (%)

10 (3%)

3 (2%)

7 (3%)

0.764

Alcohol disturbance, n (%)

46 (13%)

13 (10%)

33 (14%)

0.345

Vasculopathy, n (%)

66 (18%)

23 (19%)

43 (18%)

0.939

Cardiopathy, n (%)

31 (9%)

12 (10%)

19 (8%)

0.601

BMI, kg/m2, mean [SD]

26.3 [5.1]

27.1 [5.0]

25.9 [5.1]

0.030

McCabe score

   

0.924

0, n (%)

249 (69%)

85 (69%)

164 (69%)

 

1, n (%)

98 (27%)

35 (28%)

63 (27%)

 

2, n (%)

13 (4%)

4 (3%)

9 (4%)

 

Baseline intensive care data

Medical condition at admission, n (%)

300 (83%)

99 (80%)

201 (85%)

0.197

SAPS II, mean [SD]

51 [16]

52 [16]

51 [16]

0.629

SOFA, mean [SD]

9 [4]

10 [4]

9 [4]

0.182

PaO2/FiO2, mean [SD]

117 [42]

115 [40]

118 [43]

0.704

Plateau pressure, cm H2O, mean [SD]†

24 [6]

23 [4]

24 [6]

0.029

PEEP, cm H2O, mean [SD]†

10 [3]

9 [3]

10 [4]

0.047

Driving pressure, cm H2O, mean [SD]†

14 [5]

13 [4]

14 [5]

0.038

Tidal volume over ideal body weight, mL/kg, mean [SD]†

6.6 [1.1]

6.6 [1.1]

6.5 [1.1]

0.218

FiO2, %, mean [SD]†

77 [20]

75 [20]

77 [21]

0.361

Steroids, n (%)

80 (22%)

22 (18%)

58 (25%)

0.177

Shock at baseline, n (%)

222 (62%)

81 (65%)

141 (60%)

0.301

Renal replacement therapy, n (%)

91 (25%)

34 (27%)

57 (24%)

0.582

Primary lung injury

   

0.341

Pneumonia, n (%)

174 (48%)

52 (42%)

122 (52%)

 

Non-pulmonary infection, n (%)

73 (20%)

28 (23%)

45 (19%)

 

Aspiration, n (%)

79 (22%)

31 (25%)

48 (20%)

 

Trauma, n (%)

7 (2%)

4 (3%)

3 (1%)

 

Other, n (%)

27 (8%)

9 (7%)

18 (8%)

 

Outcomes

Ventilator-free days to day 28, days, mean [SD]

13 [10]

15 [9]

13 [10]

0.151

ICU LOS, days, mean [SD]

17 [16]

17 [14]

17 [17]

0.917

  1. ARDS, acute respiratory distress syndrome; BMI, body mass index; COPD, chronic obstructive pulmonary disease; FiO2, fraction of inspired oxygen; ICU, intensive care unit; LOS, length of stay; PaO2, partial pressure of oxygen in arterial blood; PEEP, positive end expiratory pressure; SAPS II, simplified acute physiology score II; SOFA, Sequential Organ Failure Assessment score
  2. *Both groups reported patients in the per-protocol analysis
  3. ‡p values are reported between focal and non-focal ARDS (p value < 0.05 are in bold type)
  4. †The reported variables were assessed during the first day after inclusion
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Critical Care

ISSN: 1364-8535