Sample | Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | Interaction p valuesa |
---|
First quartile | Ref | Ref | Ref | Ref | Ref | – |
Second quartile | − 0.35 (− 0.47, − 0.22) | − 0.30 (− 0.44, − 0.16) | − 0.29 (− 0.43, − 0.14) | − 0.28 (− 0.43, − 0.13) | − 0.29 (− 0.43, − 0.14) | < 0.001b |
Third quartile | − 0.69 (− 0.81, − 0.56) | − 0.63 (− 0.78, − 0.49) | − 0.62 (− 0.77, − 0.47) | − 0.62 (− 0.77, − 0.47) | − 0.62 (− 0.77, − 0.47) | < 0.001c |
Fourth Quartile | − 0.86 (− 0.98, − 0.74) | − 0.80 (− 0.95, − 0.66) | − 0.79 (− 0.95, − 0.64) | − 0.79 (− 0.94, − 0.64) | − 0.79 (− 0.94, − 0.64) | 0.037d |
- Model 1, model adjusted for type of hospitals, geographic location, site of infection (sites of bloodstream, urinary, skin, central nervous system, lung, bone, abdominal, gastrointestinal), the proportion of APACHE II score ≥ 15, and proportion of age ≥ 60
- Model 2, adjusted for model 1 + microbiology specimen collection before antibiotic therapy
- Model 3, adjusted for model 2 + infection management, infection training, infection monitor, infection contingency plan, infection performance
- Model 4, adjusted for model 3 + adherence to 3-h bundle
- aInteraction p values comparisons of Model 4 between case volume quartiles were made using the Turkey's test
- bComparison between second quartile and first quartile
- cComparison between third quartile and second quartile
- dComparison between fourth quartile and third quartile