Table 1 Literature search and characteristics of the included studies
Study, year | Country | Design | Population | Sample size (male) | Age, year | Follow-up, day | Outcome | Variables in the multivariate model |
|---|---|---|---|---|---|---|---|---|
Muller, 2001 | Switzerland | Prospective cohort study | critically ill patients (SIRS, sepsis, severe sepsis, septic shock) | 101 | – | – | OR, AUC | Univariate |
Wagenaar, 2009 | Indonesia | Prospective cohort study | severe leptospirosis | 52 (37) | 45 (32–55) | 14 | OR, AUC | Univariate |
Mauri, 2010 | Italy | Prospective cohort study | severe sepsis and septic shock | 90 (56) | 61 ± 15 | 90 | PTX3 level, AUC | Univariate |
Huttunen, 2011 | Finland | Prospective cohort study | bacteremia | 132 (70) | 62 (18–93) | 30 | OR, PTX3 level | Univariate |
Bastrup-Birk, 2013 | Denmark | Prospective cohort study | systemic inflammatory response syndrome | 261 (139) | 63 (18–88) | 873 | HR | Multivariate: age, gender |
Lin, 2013 | China | Prospective cohort study | ventilator-associated pneumonia | 136 (80) | 65 ± 3 | 28 | HR, PTX3 level, AUC | Multivariate: age, history of COPD, SOFA score, PO2/FiO2, creatinine |
Uusitalo-Seppa¨la¨, 2013 | Finland | Prospective cohort study | suspected infection | 537 (310) | 64 (18–100) | 365 | OR, PTX3 level, AUC | ICU stay, hypotension, use of vasopressors, disseminated intravascular coagulation, decreased Glasgow Coma Scale, Sepsis + organ dysfunction, multi-organ failure |
Hansen, 2016 | Denmark | Prospective cohort study | necrotizing soft tissue infections | 135 (84) | 61 (52–69) | 510 | HR, AUC | Multivariate: age, sex, Simplified Acute Physiology Score II, and chronic disease |
Fan, 2017 | Taiwan, China | Case–control study | acute decompensated cirrhotic patients | 108 (71) | 57.6 ± 11 | 90 | HR | Multivariate: no parameters provided |
Jie, 2017 | China | Prospective cohort study | ICU septic shock | 112 (55) | 58.9 ± 13.9 | 28 | HR, PTX3 level | Multivariate: no parameters provided |
Kim, 2017 | Korea | Prospective cohort study | severe sepsis | 83 (47) | 71 (64–77) | 28 | HR, PTX3 level, AUC | Univariate |
Albert Vega, 2018 | France | Case control study | septic shock | 30 (21) | 65 (19–86) | 10 | PTX3 level | Univariate |
Hu, 2018 | China | Prospective cohort study | sepsis and septic shock | 141 (86) | 64 (33–78) | 28 | HR, PTX3 level, AUC | Multivariate: no parameters provided |
Hansen, 2020 | Denmark | Prospective cohort study | ICU patients | 547 (282) | 66 (57–75) | 28 | HR, PTX3 level, AUC | Multivariate: age, sex, chronic disease and immunosuppression |
Martin, 2020 | Spain | Prospective cohort study | ICU septic shock | 75 (53) | 64 (49–74) | – | OR, PTX3 level, AUC | Multivariate: age, sex, and immunosuppression |
Song, 2020 | Korea | Prospective cohort study | sepsis and septic shock | 160 (90) | 77 (67–83) | 28 | HR, PTX3 level, AUC | Multivariate: age, positive blood culture, CRP, septic shock |
Vassalli, 2020 | Italy | Retrospective cohort study | septic patients | 958 | – | 90 | HR | Multivariate: troponin T, NT-proBNP, treatment |