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Table 1 Distribution of covariates of interest in the unadjusted and weighted populations

From: Early intubation and patient-centered outcomes in septic shock: a secondary analysis of a prospective multicenter study

Early intubation

Yes

No

P value

SMD

Yes

No

P value

SMD

Number of subjects

137

598

  

78

78

  

Age

66 (15)

65 (14)

0.442

0.074

67 (14)

67 (13)

0.844

0.032

Body mass index

28 (6)

27 (7)

0.070

0.164

28 (6)

27 (7)

0.536

0.099

Neurological criteria for intubation, n (%)

37 (27)

6 (1)

 < 0.001

0.26

3 (4)

4 (5)

1.000

0.062

Number of respiratory criteria for intubation

  

 < 0.001

   

0.467

0.199

 0–1

37 (27)

481 (80)

 

0.534

28 (36)

34 (44)

  

 2–3

66 (48)

107 (18)

 

0.303

39 (50.0)

37 (47)

  

 4–6

34 (25)

10 (2)

 

0.231

11 (14)

7 (9.0)

  

Pulmonary sepsis, n (%)

48 (35)

137.0 (23)

0.003

0.121

30 (39)

24 (31)

0.400

0.162

Respiratory rate (rpm)

31 (8)

26 (7)

 < 0.001

0.618

30 (7)

30 (7)

0.837

0.033

PaO2/FiO2

138 [85, 232]

275 [192, 381]

 < 0.001

0.884

141 [89, 230]

153 [102, 232]

0.423

0.020

PaCO2 (mmHg)

37 (15)

32 (8)

0.001

0.388

34 (10)

33 (11)

0.765

0.048

Accessory muscle use, n (%)

89.0 (65.0)

70.0 (11.7)

 < 0.001

0.533

43 (0.55)

36 (0.46)

0.337

0.179

Inability to clear secretions, n (%)

41.0 (29.9)

52.0 (8.7)

 < 0.001

0.212

18 (0.23)

17 (0.22)

1.000

0.031

pH

7.25 (0.15)

7.37 (0.08)

 < 0.001

1.005

7.31 (0.10)

7.31 (0.09)

0.967

0.007

Lactate (mmol/L)

4.3 [2.6, 6.6]

2.2 [1.6, 3.3]

 < 0.001

0.811

3.5 [2, 4.5]

3 [2, 5.5]

0.487

0.071

Non-respiratory SOFA

9 [7–12]

8 [6–9]

 < 0.001

0.706

8 [7, 10]

8 [7, 11]

0.970

0.032

Norepinephrine dose (mcg/kg/min)

0.59 [0.33, 1.00]

0.26 [0.15, 0.47]

 < 0.001

0.790

0.50 [0.28, 0.77]

0.51 [0.26, 0.88]

0.762

0.120

Glasgow Coma Scale

14 [9, 15]

15 [15]

 < 0.001

0.949

15 [14, 15]

15 [14, 15]

0.785

0.020

Platelet count, (1012/L)

170 (130)

170 (110)

0.953

0.006

160 (119)

151 (105)

0.614

0.081

Bilirubin, (mmol/L)

16 [9, 36]

15 [10, 27]

0.326

0.197

16 [9, 27]

15 [10, 25]

0.869

0.171

Creatinine, (mmol/L)

220 (172)

172 (153)

0.003

0.294

206 (161)

212 (184)

0.813

0.038

Renal replacement at T8

11 (8)

26 (4)

0.076

0.04

4 (5)

3 (4)

1.000

0.062

Median days of MV by center

6 [3, 7]

6 [3, 7]

0.666

0.004

5 [3, 7]

6 [3, 6]

0.727

0.139

Intubation rate by center (%)

0.22 [0.17, 0.33]

0.22 [0.17, 0.33]

0.514

0.038

0.21 [0.17, 0.32]

0.23 [0.17, 0.33]

0.600

0.072

Mortality rate by center (%)

0.23 [0.20, 0.29]

0.23 [0.20, 0.29]

0.726

0.039

0.23 [0.20, 0.29]

0.23 [0.20, 0.29]

0.801

0.007

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Critical Care

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