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Table 2 Individual and aggregated characteristics of study participants and ICU patients

From: An interventional quasi-experimental study to evaluate the impact of a rapid screening strategy in improving control of nosocomial extended-spectrum beta-lactamase-producing Enterobacterales and carbapenemase-producing organisms in critically ill patients

Among participants screened at admissions Interventional period Control period p value
n = 147 patientsa N = 86 patientsa
Patients at a high risk (%) 30 (20.4%) 29 (33.7%) 0.04
Median length of stay (days, IQR) 2.8 (1.5–5.6) 2.8 (1.7–7.1) 0.67
nEcESBL-PE carriers 10 (6.8%) 8 (9.3%) 0.68
CPO carriers 1 (0.7%) 3 (3.5%) 0.14
CPE carriers 1 (0.7%) 3 (3.5%) 0.14
Preemptive contact precautions prescribed 115 (78.2%) 70 (81.4%) 0.45
Among all participants screened weekly n = 589 patientsb n = 313 patientsb p value
Median length of stay (days, IQR)c 6.9 (2.9–12.6) 6.9 (3.8–15.1) 0.06
nEcESBL-PE carriers 19 (3.2%) 16 (5.1%) 0.22
CPO carriers 4 (0.7%) 8 (2.6%) 0.03
CPE carriers 3 (0.5%) 3 (1.0%) 0.42
Newly detected carriers 13 (2.2%) 10 (3.2%) 0.52
Contact precautions implemented at the time of detection among newly detected carriers 1/13 (7.7%) 6/10 (60%) 0.02
Colonization pressure (incidence density) n = 8884 patient-days n = 3772 patients-days p value
ESBL-PE (cases per 1000 patient-days) 15.3 [95% CI 12.8–18.1] 19.1 [95% CI 14.9–24.0] 0.13
CPO (cases per 1000 patient-days) 0.7 [95% CI 0.2–1.5] 2.9 [95% CI 1.5–5.2] 0.05
CPE (cases per 1000 patient-days) 0.4 [95% CI 0.1–1.1] 1.6 [95% CI 0.6–3.5] 0.22
Antibiotic consumption (ATC JC01) n = 8884 patient-days n = 3772 patients-days p value
Aminoglycoside (median DDD/1000 patient-days) 19.2 [95% CI 8.2–26.8] 22.5 [95% CI 18.3–29.5] 0.44
Carbapenems (median DDD/1000 patient-days) 97.0 [95% CI 66.9–129.0] 126.0 [95% CI 104.0–133.0] 0.18
Piperacillin and beta-lactamase inhibitor (median DDD/1000 patient-days) 145.0 [95% CI 128.0–168.0] 114.0 [95% CI 96.1–128.0] 0.03
Hand hygiene compliance among healthcare workers Hand hygiene opportunities = 474 Hand hygiene opportunities = 360 p value
Pooled mean of hand hygiene compliance 59.7 [95% CI 55.3–64.1] 61.1 [95% CI 56.1–66.1] 0.73
  1. aTwo patients screened at admission were readmitted during the control phase.
  2. bSix patients stayed both in the interventional and control phase.
  3. cInformation available for 151 and 312 patients in the interventional and control period.