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Table 3 Patient-centered endpoints stratified by tertiles

From: Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients — insights from the PRoVENT-COVID study: a national, multicenter, observational cohort analysis

 

Lower

Intermediate

Higher

P value

Overall cohort, N = 650, N (%)

215 (100.0)

220 (100.0)

215 (100.0)

 

Acute kidney injury

110 (52.1)

102 (46.6)

122 (56.7)

0.105

 Requiring RRT

63 (29.4)

58 (26.4)

67 (31.2)

0.535

 CVVH/CVVHDF

46 (21.5)

43 (19.5)

55 (25.6)

0.304

 Hemodialysis

3 (1.4)

7 (3.2)

7 (3.3)

0.395

 Peritoneal dialysis

0 (0.0)

0(0.0)

1 (0.5)

0.364

28-day mortality

62 (29.0)

61 (27.7)

78 (36.3)

0.116

Duration of intubation at 28 days

8.00 [4.00, 16.00]

11.00 [5.00, 21.00]

11.00 [4.00, 21.00]

0.019

 Survivors

8.00 [4.00, 18.25]

12.00 [6.00, 26.00]

14.00 [7.00, 28.00]

 < 0.001

 Non-survivors

6.50 [3.00, 13.75]

10.00 [2.00, 14.00]

5.50 [2.00, 11.00]

0.228

Tracheostomy incidence in ICU

36 (16.9%)

31 (14.1%)

43 (20%)

0.260

Intensive care unit length of stay

14.00 [9.00, 22.75]

18.00 [11.00, 28.00]

17.00 [9.50, 29.00]

0.019

 Survivors

15.00 [9.75, 27.25]

20.00 [13.00, 34.00]

23.00 [14.00, 37.00]

 < 0.001

 Non-survivors

10.50 [7.00, 17.75]

14.00 [6.00, 18.00]

9.50 [6.00, 15.00]

0.249

Hospital length of stay

20.00 [13.00, 32.00]

24.00 [15.00, 38.00]

22.00 [12.00, 39.00]

0.076

 Survivors

25.00 [16.00, 38.00]

30.00 [20.00, 44.00]

34.00 [21.50, 47.50]

0.001

 Non-survivors

10.50 [7.00, 17.75]

15.00 [6.00, 18.00]

9.50 [6.00, 15.00]

0.192

  1. CVVHD Continuous veno-venous hemodiafiltration, CVVH continuous veno-venous hemofiltration, RRT renal replacement therapy
  2. Data are shown as median [25th percentile, 75th percentile] or N (%). P values in bold text indicate statistical significance at P < 0.05