Fig. 4

Host response biomarkers reflecting inflammation, endothelial cell activation and coagulation in PS matched treated (n = 150) and control (n = 150) patients. The box represents the 25th percentile, median and 75th percentile. The whiskers represent up to 1.5 times the interquartile range. The dashed line represents the median value in healthy volunteers or the normal range in the reference clinical laboratory (for prothrombin time and platelets). The P values are derived from linear mixed models using log2-transformed biomarkers as the dependent variable and including a random slope and intercept for the change over time per patient. “Day 4 p” is the difference between groups at day 4 (obtained as the P value for the treatment coefficient in models using day 4, rather than admission, as the reference category). “ERY * time p” is the interaction term for treatment and time, i.e., whether the slope over time (from admission to day 4) differs between groups. ERY erythromycin