TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial

Table 3 Primary outcome in the TTCOV19 study

	Total	Early tracheotomy	Late tracheotomy	p-value	Difference between groups
Total number of days in mechanical ventilation (ITT)	20.4 (13.2)	19.6 (12.6)	21.1 (13.9)	0.5	− 1.52 (− 5.74; 2.81)
	18 (9;28)	16.5 (9;27.5)	20 (8;30)
	n = 150	n = 72	n = 78
Total number of days in mechanical ventilation (PP)	26.7 (11.8)	22.3 (11.9)	30.3 (10.6)	0.0064	− 8.03 (− 13.85; − 2.27)
	25 (18;34)	18 (12;30)	27 (22;36)
	n = 61	n = 27	n = 34
Total number of days in mechanical ventilation (PP survivors)	25.2 (10.2)	21.4 (9.8)	29.2 (9.3)	0.022	− 7.73 (− 14.33; − 1.13)
	24 (18;31)	19 (14;28)	26 (22;35)
	n = 35	n = 18	n = 17

Total number of days with mechanical ventilation for patients with early (≤ 7 days) versus late (≥ 10 days) tracheotomy, according to intention-to-treat (ITT), per-protocol (PP) and for patients who followed the study protocol and survived ICU care (PP survivors)
Data are expressed as the mean (SD), median (IQR) or n (%)

ISSN: 1364-8535