Skip to main content
Fig. 5 | Critical Care

Fig. 5

From: Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity

Fig. 5

COVID-19 patients who died had higher percentage of angiogenic neutrophils and greater impairments of neutrophil oxidative burst than survivors did. a–f Analysis of the angiogenic neutrophil subset in COVID-19 patients. Percentages of the CD49dbright angiogenic neutrophil subset measured at day 1 (a) and day 7 (d). Expression of VEGF-R1 on angiogenic neutrophils measured at day 1 (b) and day 7 (e); results are expressed as MFI. Soluble VEGF-R1 was quantified by ELISA at day 1 (c) and day 7 (f); results are expressed as pg/mL. g–l ROS production in response to fMLP by unprimed-neutrophils at day 1 (g) and day 7 (j), by LPS-primed neutrophils at day 1 (h) and day 7 (k), and TNFα-primed neutrophils at day 1 (i) and day 7(l). All measurements came from deceased COVID-19 patients or survivors at day 60 post-ICU inclusion. Values are means ± SEM. Statistical significance as determined by the nonparametric Mann–Whitney test is indicated. *Significantly different P < 0.05, **P < 0.01, ***P < 0.001, adjusted for age

Back to article page