Table 5 External validations of three TOR rules for predicting 1-month unfavourable neurological outcome (n = 234,294)

Criteria

1. Not witnessed by bystander

1. Not witnessed by EMS

1. Not witnessed by EMS

2. Initial non-shockable rhythm

2. Initial asystole

2. Initial asystole

3. No prehospital ROSC

3. No prehospital shock

3. No prehospital shock

4. No prehospital ROSC

4. No prehospital ROSC

5. Age >60 years

CPC 3–5, n

142,462

83,075

143,445

82,092

125,054

100,483

CPC 1–2, n

571

8186

122

8635

103

8654

Proportion of patients with CPC 1–2 (95% CI), %

0.40

8.97

0.09

9.50

0.08

7.90

(0.37–0.43)

(8.8–9.2)

(0.07–0.10)

(9.3–9.7)

(0.07–0.10)

(7.7–8.1)

Sensitivity (95% CI), %

63.2

(63.0–63.4)

< 0.001

63.6

(63.4–63.8)

< 0.001

55.5

(55.2–55.7)

< 0.001

Specificity (95% CI), %

93.5

(92.9–94.0)

< 0.001

98.6

(98.3–98.8)

< 0.001

98.8

(98.6–99.0)

< 0.001

FPR (95% CI), %

6.5

(6.0–7.1)

< 0.001

1.4

(1.2–1.7)

< 0.001

1.2

(1.0–1.4)

< 0.001

PPV (95% CI), %

99.6

(99.6–99.6)

< 0.001

99.9

(99.9–99.9)

< 0.001

99.9

(99.9–99.9)

< 0.001

NPV (95% CI), %

9.0

(8.4–9.6)

< 0.001

9.5

(8.9–10.2)

< 0.001

7.9

(7.4–8.5)

< 0.001

AUC (95% CI)

0.901

(0.900–0.903)

NA

0.920

(0.920–0.921)

NA

0.920

(0.920–0.920)

NA