Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients

Table 2 Factors associated with Day-28 mortality in critically ill patients

Variables	Univariate analysis OR	97.5 CI	p value
Shannon 16S rDNA	0.26	[0.09–0.62]	< 0.01
Shannon ITS2	0.47	[0.23–0.91]	0.03
Age	1.02	[0.97–1.08]	0.50
Sex (male)	7.56	[1.3–144]	0.06
SAPSII	1.07	[1.02–1.14]	0.01
Chronic pulmonary disease	0.82	[0.22–2.87]	0.76
COPD	1.02	[0.20–4.15]	0.98
Chronic heart disease	2.96	[0.83–12.3]	0.11
Atrial fibrillation	3.33	[0.88–12.7]	0.07
Coronary disease	2.26	[0.64–8.21]	0.20
Chronic kidney disease	1.73	[0.40–6.76]	0.44
Malignancy	13.1	[2.39–104]	< 0.01
Immunosuppression	1.17	[0.23–4.83]	0.84
Long-term proton pump inhibitor	0.89	[0.18–3.59]	0.87
Long-term metformin	1.01	[0.98–1.03]	0.99
Antibiotics within the past 3 months	0.53	[0.11–2.07]	0.39
Septic shock at admission	2.78	[0.78–10.3]	0.11
Acute respiratory distress syndrome at admission	4.44	[0.90–22.4]	0.06
Acute kidney injury at admission	14.4	[2.51–274]	0.01
Digestive infection within the past 3 months	1.75	[0.08–19.8]	0.66

Variables	Multivariate analysis OR	97.5 CI	p value
Shannon 16S rDNA	0.19	[0.04–0.60]	< 0.01
SAPSII	1.08	[1.01–1.17]	0.04
Sex (male)	14.4	[1.45–516]	0.05
Atrial fibrillation	5.03	[0.76–41.1]	0.10

Variables	Multivariate analysis OR	97.5CI	p value
Shannon ITS2	0.29	[0.09–0.75]	0.02
SAPSII	1.08	[1.02–1.17]	0.02
Sex (male)	18.8	[1.84–582]	0.04
Atrial fibrillation	4.53	[0.07–33.4]	0.11

Bold in univariate analysis: variables assessed for inclusion in the multivariate analysis. Bold in multivariate analysis: variables independently associated with Day-28 mortality
ICU intensive care unit, ITS2 internal transcribed spacer 2, OR odds ratio, SAPSII simplified acute physiology score II, 16S rDNA DNA region coding for ribosomal 16S RNA subunit, 97.5 CI 97.5% confidence interval

ISSN: 1364-8535