Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients

Table 1 Patients’ characteristics and comparison between survivors and non-survivors

	Total (n = 57)	Non-survivors (n = 13)	Survivors (n = 44)	p value
Characteristics at admission to ICU
Age	75 [65–79]	73 [65–79]	76 [64–79]	0.99
Sex (male)	39 (68.4%)	12 (92.9%)	27 (61.4%)	0.04
SAPSII	68 [49–78]	78 [75–87]	61 [46–74]	< 0.01
Septic shock	20 (35.1%)	7 (50%)	13 (29.5%)	0.18
ARDS	8 (14%)	4 (28.6%)	4 (9.1%)	0.07
Acute kidney injury	32 (56.1%)	12 (85.7%)	20 (45.5%)	< 0.01
Comorbidities
Chronic respiratory disease	24 (42.1%)	5 (35.7%)	19 (43.2%)	0.52
COPD	13 (22.8%)	3 (21.4%)	10 (22.7%)	1.00
Asthma	6 (10.5%)	1 (7.1%)	5 (11.4%)	1.00
Chronic heart failure	28 (49.1%)	9 (64.3%)	19 (43.2%)	0.12
Chronic coronary disease	22 (38.6%)	7 (50%)	15 (34.1%)	0.22
Chronic kidney disease	13 (22.8%)	4 (28.7%)	9 (20.5%)	0.47
Immunosuppression	12 (21%)	3 (21.4%)	9 (20.5%)	1.00
Active solid cancer	6 (10.5%)	4 (28.6%)	2 (4.5%)	0.02
Proton pump inhibitor	15 (26.3%)	3 (21.4%)	12 (27.3%)	1.00
Metformin	6 (10.5%)	4 (28.6%)	6 (13.6%)	0.21
Antimicrobial treatment during the 3 previous months	19 (33.3%)	3 (21.4%)	16 (36.4%)	0.51
Treatment
Mechanical ventilation	32 (56.1%)	10 (71.4%)	22 (50%)	0.12
Renal replacement therapy	10 (17.5%)	6 (42.9%)	4 (9.1%)	< 0.01

Results are presented as proportion for categorical variables and median [interquartile range] for continuous variables
p values are for comparison between survivors and non-survivors. Threshold for statistical significance: p = 0.05
ARDS acute respiratory distress syndrome, ICU intensive care unit, SAPS simplified acute physiology score II

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