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Table 3 Pharmacokinetic parameters in the studied groups based on individual estimates derived post hoc

From: Plasma disappearance rate of albumin when infused as a 20% solution

Variable

Volunteers

Post-burn

Surgery, minor hemorrhage

Surgery, major hemorrhage

Postoperative

Vc (L)a

6.2 (5.2–7.1)b

5.9 (5.4–6.4)

5.1 (4.5–5.7)

4.3 (4.2–5.0)

4.6 (4.2–5.0)

tvkb (10−4 min−1)

10.2 (7.0–13.5)

7.5 (5.8–9.2)

6.5 (4.3–8.7)

32.0 (16.8–47.4)c

10.8 (8.3–13.2)

tvkbleed (10−4 min−1)

3.4 (2.7–4.1)

2.2 (2.0–2.5)

14.0 (8.7–19.4)

88.8 (40.8–136.8)c

3.4 (2.9–3.8)

T1/2 (h)

15.8 (9.6–22.0)

17.5 (14.1–21.0)

22.6 (17.5–27.7)

4.9 (2.8–6.9)c

12.7 (9.7–15.8)

  1. Data are the mean (95% CI) and derived post hoc based on the population kinetic analysis
  2. aCalibration factor between the infused albumin mass and the increase of the plasma albumin concentration
  3. bDiffered from the two last groups P < 0.05 (Scheffé test) after one-way ANOVA P < 0001
  4. cDiffered from all other groups by P < 0.05 (Scheffé test) after one-way ANOVA P < 0001
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Critical Care

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