Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes

Table 2 Study outcomes according to serum IL-17A tertiles

	Tertile 1	Tertile 2	Tertile 3	p value
Range, fg/ml	≤ 571.7	586.9–2295.6	≥ 2313.9
No. of patients	99	100	100
Primary outcomes
Hospital mortality, n (%)	9 (9.1)	8 (8.0)	26 (26.0)	< 0.001^a,b
MAKE*, n (%)	21 (21.2)	24 (24.0)	53 (53.0)	< 0.001^a,b
Mortality	9 (9.1)	9 (9.0)	28 (28.0)	< 0.001^a,b
KRT dependence	7 (7.1)	9 (9.0)	14 (14.0)	0.244
eGFR drop of ≥ 30% from baseline	5 (5.1)	6 (6.0)	11 (11.0)	0.049
Secondary outcomes
Days in the hospital, median [IQR]	8.5 [5.0–14.8]	11.0 [6.0–20.0]	13.0 [7.0–22.0]	0.010^a
Days in the ICU, median [IQR]	4.0 [2.0–9.0]	5.0 [2.0–9.8]	8.0 [3.3–15.8]	0.004^a,b
Days on mechanical ventilation, median [IQR]	0.0 [0.0–2.0]	1.0 [0.0–4.0]	2.0 [0.0–7.8]	0.002^a,b

eGFR estimated glomerular filtration rate, ICU intensive care unit, IQR interquartile range, MAKE major adverse kidney event at 90 days post-discharge, KRT kidney replacement therapy
*Frequency of individual parameters for MAKE were evaluated in hierarchical order. First, mortality. Second, KRT dependence in survivors. Third, drop in eGFR in survivors not dependent on KRT
^aDenotes p < 0.05 for comparisons between highest and lowest tertiles
^bDenotes p < 0.05 for comparisons between highest and middle tertiles

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