From: Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes
Characteristic | Tertile 1 | Tertile 2 | Tertile 3 | p value |
---|---|---|---|---|
Range, fg/ml | ≤ 571.7 | 586.9–2295.6 | ≥ 2313.9 |  |
No. of patients | 99 | 100 | 100 | Â |
Demographics | ||||
 Age, years ± SD | 58.1 ± 14.9 | 57.0 ± 15.4 | 55.3 ± 15.4 | 0.447 |
 Women, n (%) | 49 (49.5) | 34 (34.0) | 41 (41.0) | 0.085 |
 Race, n (%) |  |  |  |  |
  White | 77 (77.8) | 76 (76.0) | 82 (82.0) | 0.794 |
  Black | 11 (11.1) | 10 (10.0) | 7 (7.0) |  |
  Other | 11 (11.1) | 14 (14.0) | 11 (11.0) |  |
 Body mass index, kg/m2 | 30.9 [24.9–35.9] | 27.8 [24.0–36.28] | 27.1 [22.9–34.9] | 0.327 |
Baseline kidney function | ||||
 Baseline eGFR, ml/min/1.73 m2, median [IQR] | 88.4 [73.1–99.0] | 88.6 [75.7–101.9] | 90.9 [80.6–102.1] | 0.409 |
 Baseline SCr, mg/dl, median [IQR] | 0.9 [0.7–1.0] | 0.9 [0.8–1.0] | 0.8 [0.7–1.0] | 0.624 |
Comorbidity | ||||
 Diabetes, n (%) | 28 (28.3) | 22 (22.0) | 27 (27.0) | 0.563 |
 Hypertension, n (%) | 52 (52.5) | 50 (50.0) | 53 (53.0) | 0.901 |
 CHF, n (%) | 32 (32.3) | 23 (23.0) | 18 (18.0) | 0.094a |
 Liver disease, n (%) | 14 (14.1) | 11 (11.0) | 27 (27.0) | 0.007a,b |
 Anemia*, n (%) | 43 (43.4) | 54 (54.0) | 62 (62.0) | 0.025a |
 Cancer, n (%) | 34 (34.3) | 21 (21.0) | 26 (26.0) | 0.091 |
 Charlson comorbidity index, median [IQR] | 3.0 [2.0–5.0] | 3.0 [1.0–5.0] | 3.0 [2.0–5.0] | 0.501 |
Critical illness parameters | ||||
 SCr at first timepoint (t1), mg/dl, median [IQR] | 0.9 [0.7–1.7] | 1.0 [0.7–2.6] | 2.0 [1.0–3.0] | < 0.001a,b |
 Acute kidney injury, n (%) | 33 (33.3) | 47 (47.0) | 73 (73.0) | < 0.001a,b |
 CFB 72 h, L, median [IQR] | 1.7 [− 0.4 to 4.1] | 1.7 [0.2–4.6] | 3.9 [0.4–7.6] | 0.020a,b |
 Pressor or inotrope, n (%) | 53 (53.5) | 44 (44.0) | 63 (63.0) | 0.027b |
 Mechanical ventilation, n (%) | 44 (44.4) | 48 (48.0) | 63 (63.0) | 0.021a,b |
 Packed RBC transfusion, n (%) | 28 (28.3) | 34 (34.0) | 53 (53.0) | 0.001a,b |
 Non-renal APACHE II score, median [IQR] | 14.0 [10.0–19.0] | 15.5 [10.8–22.0] | 19.0 [14.0–23.3] | < 0.001a,b |
 Non-renal SOFA score, median [IQR] | 5.00 [2.0–8.0] | 5.0 [2.0–9.3] | 7.00 [4.0–11.0] | 0.006a,b |