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Table 3 Time to recovery and all-cause mortality by oxygen delivery mode and baseline imputed PaO2/FiO2 at baseline

From: Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial

Oxygen delivery at baseline

HFNC

 

Placebo

(n = 82)

Auxora

(n = 81)

Difference

(95% CI)

P value

Median time to recovery, days (95% CI)

17.0 (8.0, 30.0)

9.0 (7.0, 13.0)

 

0.1079

All-Cause Mortality at Day 60, n (%)

21 (25.6%)

13 (16.0%)

−9.36

(−21.79, 3.07)

0.1436

Low flow oxygen

 

Placebo

(n = 49)

Auxora

(n = 49)

Difference

(95% CI)

P value

Median time to recovery, days (95% CI)

7.0 (5.0, 9.0)

5.0 (4.0, 6.0)

 

0.4195

All-Cause Mortality at Day 60, n (%)

6 (12.2%)

5 (10.2%)

−2.04

(−14.53, 10.45)

0.7490

Baseline imputed PaO2/FiO2 at baseline

 ≤ 100

 

Placebo

(n = 58)

Auxora

(n = 59)

Difference

(95% CI)

P value

Median time to recovery, days (95% CI)

23.0 (11.0, 70.0)

11.5 (8.0, 23.0)

 

0.1040

All-Cause Mortality at Day 60, n (%)

17 (29.3%)

12 (20.3%)

−8.62

(−24.30, 7.06)

0.2837

101–200

 

Placebo

(n = 73)

Auxora

(n = 71)

Difference

(95% CI)

P Value

Median time to recovery, days (95% CI)

7.0 (5.0, 8.0)

6.0 (5.0, 7.0)

 

0.4156

All-Cause Mortality at Day 60, n (%)

10 (13.7%)

6 (8.5%)

−5.25

(−15.45, 4.95)

0.3164

  1. Definition of Recovery by Ordinal Scale: 6 Hospitalized, not requiring supplemental oxygen or ongoing medical care; 7 Discharged, requiring supplemental oxygen; 8 Discharged, not requiring supplemental oxygen. Kaplan–Meier estimate of Days to Recovery with P value based on log-rank test without stratification. Unstratified analysis of mortality using Chi-squared test. HFNC, high flow nasal cannula. Patients with a baseline imputed PaO2/FiO2 > 200 were excluded from the efficacy set analysis