Table 2 Primary and secondary outcomes
Outcome | All patients (n = 2137) | No early prone position group (n = 1646) | Early prone position group (n = 491) | p |
|---|---|---|---|---|
Primary outcome | ||||
Mortality at Day-60, n (%) | 756 (35.4%) | 563 (34.2%) | 193 (39.3%) | 0.038 |
Secondary outcomes | ||||
Mortality, n (%) | ||||
At Day-28 | 652 (30.5%) | 482 (29.3%) | 170 (34.6%) | 0.024 |
At Day-90 | 767 (35.9%) | 574 (34.9%) | 193 (39.3%) | 0.072 |
Ventilatory-free days util Day-28, median (IQR) | 6 (0–16) | 7 (0–17) | 0 (0–14) | < 0.001 |
Extracorporeal membrane oxygenation, n (%) | 221 (10.4%) | 151 (9.2%) | 70 (14.3%) | 0.001 |
Extracorporeal CO2 removal, n (%) | 10 (0.7%) | 7 (0.7%) | 3 (0.9%) | 0.719 |
Inhaled nitric oxide, n (%) | 412 (19.3%) | 286 (17.4%) | 126 (25.7%) | < 0.0001 |
Static compliance (mL/cmH2O), median (IQR) | ||||
At Day-3 | 33.6 (25.7–42.5) | 34.4 (26.7–43.6) | 31.4 (23.4–40) | < 0.001 |
At Day-5 | 31.4 (24.3–40) | 32.3 (24.7–40.8) | 29.4 (22.6–39.7) | 0.011 |
At Day-7 | 31 (22.9–40) | 31.4 (23.3–40.4) | 29.4 (22.1–38.8) | 0.105 |
SOFA score, median (IQR) | ||||
At Day-7 | 9 (7–12) | 9 (7–11) | 10 (8–12) | 0.002 |
At Day-21 | 8 (6.2–11) | 8 (7–12) | 8 (5–11) | 0.638 |
At Day-28 | 8 (6.5–11) | 8 (6–11) | 9 (7–11) | 0.905 |
PaO2/FiO2 ratio (mmHg), median (IQR) | ||||
At Day-3 | 158.3 (118.3–213.3) | 162.9 (121.2–220) | 148 (108.7–192.5) | < 0.0001 |
At Day-5 | 155 (113.3–205.5) | 158.3 (115–208.6) | 140 (106–191.4) | 0.001 |
At Day-7 | 157.1 (114–205) | 158.3 (116–209.3) | 150 (104.4–187.5) | 0.002 |
Number of prone sessions during ICU stay, median (IQR) | 3 (2–6) | 3 (2–6) | 4 (2–7) | < 0.0001 |
Delay between ICU admission and 1st prone position, days, median (IQR) | 2 [0–4] | 3 [2–5] | 0 [0–0] | |