The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study

Table 4 Multivariate analysis of clinical factors associated with treatment outcomes after propensity score matching

	28-Day all-cause mortality^a		Favorable clinical outcomes on day 14^b		Microbiological eradication day 14^b
	aHR (95% CI)	P value	aOR (95% CI)	P value	aOR (95% CI)	P value
Loading dose	0.59 (0.34–1.01)	0.054	2.24 (1.12–4.52)	0.024	2.80 (1.10–7.12)	0.031
Age	1.01 (0.99–1.02)	0.594	1.00 (0.97–1.02)	0.650	1.01 (0.99–1.04)	0.334
Male	1.35 (0.77–2.35)	0.291	1.51 (0.74–3.09)	0.255	1.23 (0.49–3.13)	0.659

^aAdjusted hazard ratio (aHR) and 95% confidence interval (CI) were derived from Cox regression analysis
^bAdjusted odds ratios (aORs) and 95% CIs were derived from logistic regression analysis

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