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Table 3 Therapeutic efficacy and acute kidney injury in the loading dose and nonloading dose groups after propensity score matching

From: The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study

 

Nonloading dose (n = 67)

Loading dose (n = 67)

P value

Length of hospital stay (days), M (R)

60 (20–220)

52 (14–284)

0.037a

Length of ICU stay (days), M (R)

22 (3–215)

20 (7–95)

0.765a

28-day ventilator weaning

34 (53.1)

29 (44.6)

0.429

Mortality (since pneumonia onset)

 Day 7, n (%)

6 (9.0)

5 (7.5)

1.000

 Day 14, n (%)

19 (28.4)

10 (14.9)

0.093

 Day 28, n (%)

33 (49.3)

22 (32.8)

0.079

 In-hospital mortality, n (%)

42 (62.7)

32 (47.8)

0.118

Favorable clinical outcomes

 Day 7

23 (49.3)

39 (58.2)

0.386

 Day 14

24 (35.8)

37 (55.2)

0.037

 Day 28

26 (38.8)

37 (55.2)

0.083

Microbiological eradication

 Day 7

2 (5.0)

7 (20.0)

0.101

 Day 14

12 (27.3)

19 (50.0)

0.042

 Day 28

19 (45.2)

26 (60.5)

0.234

Acute kidney injury

27 (50.0)

31 (55.4)

0.710

  1. M (R): Median (range); a Mann–Whitney U test; MV: Mechanical ventilation
  2. The assessment of hospital and ICU stays did not include patients who died during hospitalization
  3. Definition of acute kidney injury: creatinine increase ≥ 0.3 mg/dL within 2 days or ≥ 50% from baseline within 7 days according to the KDIGO criteria; The comparison of AKI did not include the patients who were receiving renal replacement therapy at baseline and those who lacked adequate creatinine data for the assessment of AKI