| Nonloading dose (n = 67) | Loading dose (n = 67) | P value |
---|---|---|---|
Age, M (SD) | 68.79 (16.83) | 69.78 (14.66) | 0.718 |
Sex, n (%) | 1.000 | ||
 Female | 29 (43.3) | 29 (43.3) |  |
 Male | 38 (56.7) | 38 (56.7) |  |
Height, M (SD) | 160.17 (10.44) | 161.83 (7.92) | 0.326 |
Weigh, M (SD) | 58.8 (15.61) | 60.33 (15.31) | 0.580 |
BMI, M (SD) | 22.38 (6.03) | 23.00 (5.45) | 0.553 |
Smoking | 24 (36.4) | 23 (34.3) | 0.949 |
Alcohol consumption | 10 (14.9) | 10 (15.2) | 1.000 |
Pathogen, n (%) | 0.867 | ||
 CR-Pseudo | 5 (7.5) | 6 (9.0) |  |
 CRAB | 59 (88.1) | 57 (85.1) |  |
 CRKP | 3 (4.5) | 4 (6.0) |  |
Pneumonia types, n (%) | 0.464 | ||
 HAP | 20 (29.9) | 25 (37.3) |  |
 VAP | 47 (70.1) | 42 (62.7) |  |
ICU types, n (%) | 0.827 | ||
 Medical ICU | 55 (82.1) | 53 (79.1) |  |
 Surgical ICU | 12 (17.9) | 14 (20.9) |  |
Comorbidities | |||
 Lung cancer, n (%) | 1 (1.5) | 2 (3.0) | 1.000 |
 Malignancy | 8 (11.9) | 8 (11.9) | 1.000 |
 Liver disease | 7 (10.4) | 8 (11.9) | 1.000 |
 Heart failure | 9 (13.4) | 8 (11.9) | 1.000 |
 Hypertension | 34 (50.7) | 35 (52.2) | 1.000 |
 Stroke | 10 (14.9) | 11 (16.4) | 1.000 |
 Degenerative brain disease | 9 (13.4) | 7 (10.4) | 0.790 |
 Renal insufficiency | 7 (14.9) | 12 (27.9) | 0.210 |
 Lung diseases | 19 (28.4) | 17 (25.4) | 0.845 |
 Diabetes | 28 (41.8) | 27 (40.3) | 1.000 |
 Autoimmune disease | 5 (7.5) | 4 (6.0) | 1.000 |
Coadministered antibiotics | |||
 Sulbactam, n (%) | 2 (3.0) | 1 (1.5) | 1.000 |
 Carbapenem | 27 (40.3) | 24 (35.8) | 0.722 |
 Tigecycline | 32 (47.8) | 30 (44.8) | 0.862 |
 Inhaled colistin | 27 (40.3) | 27 (40.3) | 1.000 |
Disease severity | |||
 APACHE II score, M (SD) | 22.29 (8.38) | 23.37 (8.33) | 0.464 |
 SOFA score (ICU admission date), M (SD) | 8.54 (3.63) | 9.39 (3.81) | 0.188 |
 SOFA score (pneumonia index date), M (SD) | 8.46 (3.69) | 8.63 (3.36) | 0.788 |
 Septic shock | 12 (17.9) | 18 (26.9) | 0.300 |
 Invasive ventilation | 58 (86.6) | 61 (91.0) | 0.584 |
 PF ratio, M (SD) | 261.24 (121.82) | 249.85 (134.43) | 0.623 |
 Dialysis (HD + CVVH) | 13 (19.4) | 8 (11.9) | 0.342 |
Lab data analysis | |||
 Leukocyte, M (SD) | 13,402.39 (8335.61) | 13,190.24 (8479.92) | 0.884 |
 C-reactive protein, M (SD) | 14.56 (28.26) | 11.31 (8.62) | 0.396 |
 Albumin, M (SD) | 2.57 (0.57) | 2.58 (0.51) | 0.852 |
 Creatinine, M (SD) | 1.97 (1.88) | 2.07 (2.03) | 0.755 |