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Table 2 Demographic characteristics and disease severities of ICU patients treated with a nonloading dose or loading dose of colistin after propensity-score matching

From: The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study

 

Nonloading dose (n = 67)

Loading dose (n = 67)

P value

Age, M (SD)

68.79 (16.83)

69.78 (14.66)

0.718

Sex, n (%)

1.000

 Female

29 (43.3)

29 (43.3)

 

 Male

38 (56.7)

38 (56.7)

 

Height, M (SD)

160.17 (10.44)

161.83 (7.92)

0.326

Weigh, M (SD)

58.8 (15.61)

60.33 (15.31)

0.580

BMI, M (SD)

22.38 (6.03)

23.00 (5.45)

0.553

Smoking

24 (36.4)

23 (34.3)

0.949

Alcohol consumption

10 (14.9)

10 (15.2)

1.000

Pathogen, n (%)

0.867

 CR-Pseudo

5 (7.5)

6 (9.0)

 

 CRAB

59 (88.1)

57 (85.1)

 

 CRKP

3 (4.5)

4 (6.0)

 

Pneumonia types, n (%)

0.464

 HAP

20 (29.9)

25 (37.3)

 

 VAP

47 (70.1)

42 (62.7)

 

ICU types, n (%)

0.827

 Medical ICU

55 (82.1)

53 (79.1)

 

 Surgical ICU

12 (17.9)

14 (20.9)

 

Comorbidities

 Lung cancer, n (%)

1 (1.5)

2 (3.0)

1.000

 Malignancy

8 (11.9)

8 (11.9)

1.000

 Liver disease

7 (10.4)

8 (11.9)

1.000

 Heart failure

9 (13.4)

8 (11.9)

1.000

 Hypertension

34 (50.7)

35 (52.2)

1.000

 Stroke

10 (14.9)

11 (16.4)

1.000

 Degenerative brain disease

9 (13.4)

7 (10.4)

0.790

 Renal insufficiency

7 (14.9)

12 (27.9)

0.210

 Lung diseases

19 (28.4)

17 (25.4)

0.845

 Diabetes

28 (41.8)

27 (40.3)

1.000

 Autoimmune disease

5 (7.5)

4 (6.0)

1.000

Coadministered antibiotics

 Sulbactam, n (%)

2 (3.0)

1 (1.5)

1.000

 Carbapenem

27 (40.3)

24 (35.8)

0.722

 Tigecycline

32 (47.8)

30 (44.8)

0.862

 Inhaled colistin

27 (40.3)

27 (40.3)

1.000

Disease severity

 APACHE II score, M (SD)

22.29 (8.38)

23.37 (8.33)

0.464

 SOFA score (ICU admission date), M (SD)

8.54 (3.63)

9.39 (3.81)

0.188

 SOFA score (pneumonia index date), M (SD)

8.46 (3.69)

8.63 (3.36)

0.788

 Septic shock

12 (17.9)

18 (26.9)

0.300

 Invasive ventilation

58 (86.6)

61 (91.0)

0.584

 PF ratio, M (SD)

261.24 (121.82)

249.85 (134.43)

0.623

 Dialysis (HD + CVVH)

13 (19.4)

8 (11.9)

0.342

Lab data analysis

 Leukocyte, M (SD)

13,402.39 (8335.61)

13,190.24 (8479.92)

0.884

 C-reactive protein, M (SD)

14.56 (28.26)

11.31 (8.62)

0.396

 Albumin, M (SD)

2.57 (0.57)

2.58 (0.51)

0.852

 Creatinine, M (SD)

1.97 (1.88)

2.07 (2.03)

0.755

  1. M (SD): Mean (standard deviation)