Table 1 Demographic characteristics and disease severities of ICU patients treated with nonloading or loading colistin
|  | Nonloading dose (n = 127) | Loading dose (n = 85) | P value |
|---|---|---|---|
Age, M (SD) | 69.67 (15.73) | 69.42 (14.50) | 0.909 |
Sex, n (%) | 0.823 | ||
 Female | 51 (40.2) | 32 (37.6) |  |
 Male | 76 (59.8) | 53 (62.4) |  |
Height, M (SD) | 161.97 (10.14) | 161.49 (7.94) | 0.717 |
Weigh, M (SD) | 60.08 (14.54) | 60.13 (15.80) | 0.983 |
BMI, M (SD) | 22.55 (5.03) | 23.10 (5.70) | 0.479 |
Smoking | 44 (35.2) | 32 (37.6) | 0.829 |
Alcohol consumption | 23 (18.4) | 15 (17.9) | 1.000 |
Pathogen, n (%) | 0.052 | ||
 CR-Pseudo | 8 (6.3) | 8 (9.4) |  |
 CRAB | 115 (90.6) | 68 (80.0) |  |
 CRKP | 4 (3.1) | 9 (10.6) |  |
Pneumonia types, n (%) | 0.001 | ||
 HAP | 27 (21.3) | 38 (44.7) |  |
 VAP | 100 (78.7) | 47 (55.3) |  |
ICU types, n (%) | 0.063 | ||
 Medical ICU | 89 (70.1) | 70 (82.4) |  |
 Surgical ICU | 38 (29.9) | 15 (17.6) |  |
Comorbidities | |||
 Lung cancer, n (%) | 8 (6.3) | 2 (2.4) | 0.322 |
 Malignancy | 17 (13.4) | 9 (10.6) | 0.693 |
 Liver disease | 14 (11.0) | 13 (15.3) | 0.481 |
 Heart failure | 14 (11.0) | 11 (12.9) | 0.836 |
 Hypertension | 69 (54.3) | 40 (47.1) | 0.369 |
 Stroke | 20 (15.7) | 12 (14.1) | 0.897 |
 Degenerative brain disease | 16 (12.6) | 8 (9.4) | 0.620 |
 Renal insufficiency | 17 (17.0) | 14 (29.2) | 0.137 |
 Lung disease | 22 (17.3) | 26 (30.6) | 0.036 |
 Diabetes | 43 (33.9) | 33 (38.8) | 0.553 |
 Autoimmune disease | 11 (8.7) | 6 (7.1) | 0.870 |
Coadministered antibiotics | |||
 Sulbactam, n (%) | 6 (4.7) | 1 (1.2) | 0.247 |
 Carbapenem | 60 (47.2) | 27 (31.8) | 0.035 |
 Tigecycline | 40 (31.5) | 42 (49.4) | 0.013 |
 Inhaled colistin | 50 (39.4) | 35 (41.2) | 0.904 |
Disease severity | |||
 APACHE II score, M (SD) | 22.30 (8.30) | 23.86 (8.09) | 0.187 |
 SOFA score (ICU admission date), M (SD) | 7.80 (3.83) | 9.71 (3.68) | < 0.001 |
 SOFA score (pneumonia index date), M (SD) | 8.04 (3.56) | 9.35 (3.65) | 0.010 |
 Septic shock | 21 (16.5) | 27 (31.8) | 0.015 |
 Invasive ventilator | 109 (85.8) | 79 (92.9) | 0.167 |
 PF ratio, M (SD) | 269.21 (120.24) | 255.27 (139.94) | 0.462 |
 Dialysis (HD + CVVH) | 21 (16.5) | 14 (16.5) | 1.000 |
Lab data analysis | |||
 Leukocyte, M (SD) | 13,441.97 (8020.94) | 13,968.54 (9484.37) | 0.664 |
 C-reactive protein, M (SD) | 13.47 (21.66) | 11.94 (8.96) | 0.557 |
 Albumin, M (SD) | 2.63 (0.56) | 2.55 (0.48) | 0.280 |
 Creatinine, M (SD) | 2.07 (1.78) | 2.14 (2.06) | 0.773 |