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Fig. 5 | Critical Care

Fig. 5

From: The pathogens of secondary infection in septic patients share a similar genotype to those that predominate in the gut

Fig. 5

a. Time points of intestinal and secondary infections. The bar chart represents the microbiome composition at the genus level at different time points for individual patients. The triangle indicates the time of Klebsiella or Enterococcus intestinal predominance, and the bar indicates the secondary infection time. In Patient A, the intestinal Klebsiella predominance time was Day 5, and the secondary bloodstream infection time was Day 32. In Patient B, the intestinal Klebsiella predominance time was Day 3, and the systemic bloodstream infection time was Day 26. In Patient C, the intestinal Klebsiella predominance time was Day 3, and the secondary bloodstream infection time was Day 6. In Patient D, the intestinal Klebsiella predominance time was Day 1, and the secondary bloodstream infection time was Day 2. In Patient E, the intestinal Klebsiella predominance time was Day 1, and the secondary bloodstream infection time was Day 47. In Patient E, the intestinal Enterococcus predominance time was Day 5, and the secondary abdominal infection time was Day 24. b. Comparison of the intestinal metagenomic sequences and cultured bacteria sequences from patients. Using the concatenated draft genome of cultured bacteria from each patient as a reference, the intestinal metagenomic sequences were mapped to the reference, and SNPs are illustrated in the first (outer) circle. The second circle represents the region of the reference genome covered by the metagenome sequences (red). The third and fourth circles (innermost) show the genome comparison result for one randomly downloaded complete genome from NCBI with the reference draft genome (blue), with the third circle representing SNPs and the fourth circle representing coverage. The gaps in the circles indicate that this region was not covered by a metagenomic sequence (the second circle) or other known genomes (the fourth circle)

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