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Table 1 Causes of acquired FXIII deficiency.

From: The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing

 

Pathophysiology

Associated conditions

Immune

Autoantibody-mediated inhibition or rapid clearance

Autoimmune disease

 Systemic lupus erythematosus (SLE)

 Rheumatoid arthritis

Malignancy

 Solid tumours

 Haematologic malignancy

Medications

 Isoniazid

Monoclonal gammopathy of undetermined significance (MGUS)

Non-immune

Hyper-consumption

Surgery

Disseminated intravascular coagulation (DIC)

Inflammatory bowel disease

Henoch-Schoenlein purpura (HSP)

Sepsis

Thrombosis

Pulmonary embolism, stroke

Hypo-synthesis

Liver disease

Leukaemia

Medications

 Valproate

 Tocilizumab