From: The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing
 | Pathophysiology | Associated conditions |
---|---|---|
Immune | Autoantibody-mediated inhibition or rapid clearance | Autoimmune disease  Systemic lupus erythematosus (SLE)  Rheumatoid arthritis Malignancy  Solid tumours  Haematologic malignancy Medications  Isoniazid Monoclonal gammopathy of undetermined significance (MGUS) |
Non-immune | Hyper-consumption | Surgery Disseminated intravascular coagulation (DIC) Inflammatory bowel disease Henoch-Schoenlein purpura (HSP) Sepsis Thrombosis Pulmonary embolism, stroke |
Hypo-synthesis | Liver disease Leukaemia Medications  Valproate  Tocilizumab |