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Table 4 Multivariable linear regression analysis of early (day 1) predictors of 5-day changes in LUS indices. Changes in pO2/FiO2 and in dead space indices between timepoint sp1 and sp0 (sp0-1) were included in the analysis (n = 187). CO2 response was assessed by using either VR (panel A) or MVcorr (panel B)

From: Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study

Parameter

r

SE

p

VIF

R2

R2adj

Panel A

Δ Global LUS

Initial LUS

− 0.51

 

< 0.001

0.05

0.66

0.65

CO2 responder (VR sp0-1)

− 0.39

 

0.009

1.44

  

Not included in the model

      

O2 responder (pO2/FiO2 sp0-1)

− 0.19

 

0.391

1.22

  

PEEP (day 1)

− 0.13

 

0.151

1.51

  

Δ global N-consolidations

Initial N-consolidations

− 0.51

 

0.001

0.18

0.68

0.67

CO2 responder (VR sp0-1)

− 0.45

 

0.001

1.41

  

Not included in the model

      

O2 responder (pO2/FiO2 sp0-1)

− 0.21

 

0.29

1.21

  

PEEP (day 1)

0.34

 

0.16

1.30

  

Global reaeration score

Initial LUS

0.55

 

0.001

0.09

0.65

0.64

CO2 responder (VR sp0-1)

0.44

 

0.009

1.37

  

Not included in the model

      

PEEP (day 1)

0.29

 

0.138

1.29

0.65

0.64

O2 responder (pO2/FiO2 sp0-1)

0.16

 

0.479

1.13

  

Panel B

Δ Global LUS

CO2 responder (MVcorr sp0-1)

− 0.39

 

0.02

1.47

0.64

0.62

Initial LUS

− 0.51

 

< 0.001

1.31

  

Not included in the model

      

O2 responder (pO2/FiO2 sp0-1)

− 0.19

 

0.41

1.06

  

PEEP (day 1)

0.24

 

0.16

1.08

  

Δ global N-consolidations

CO2 responder (MVcorr sp0-1)

− 0.36

 

0.010

1.50

0.68

0.67

Initial N-consolidations

− 0.51

 

0.002

1.30

  

Not included in the model

      

O2 responder (pO2/FiO2 sp0-1)

− 0.21

 

0.390

1.05

  

PEEP (day 1)

0.31

 

0.091

1.28

  

Global reaeration score

CO2 responder (MVcorr sp0-1)

0.39

 

0.009

1.45

0.64

0.63

Initial LUS

0.50

 

0.001

1.27

  

Not included in the model

      

O2 responder (pO2/FiO2sp0-1)

0.16

 

0.381

1.04

  

PEEP (day 1)

0.29

 

0.253

1.13

  
  1. Δ global LUS score, global Lung Ultrasonographic Score (LUS) (day 5) + global LUS (day 0); Δ global N-consolidations, global N-areas with consolidations (i.e., score 3) at day 5 − global N-areas with consolidations (i.e., score 3) at day 0; MVcorr, corrected Minute Ventilation; PEEP, positive end-expiratory pressure; r, partial correlation coefficient; R2, coefficient of determination; R2 adj, adjusted R2; SE, standard error; VIF, variance inflation factor; VR, ventilatory ratio. Statistically significant associations are written in bold characters
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Critical Care

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