Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study

Table 3 Cox multivariable analysis of predictors of 28-day NIV failure, death and endotracheal intubation (ETI), after inclusion of gas exchange responses and PEEP at day 1 in supine position (timepoint sp1). CO2 response was assessed via ventilatory ratio (VR) (n = 182)

Parameter	HR	95% CI	p
NIV failure
Age	1.0241	0.9969–1.0520	0.084
SAPS II	1.0324	0.9886–1.0782	0.151
PP therapy	0.2538	0.1401–0.4597	< 0.001
paO2/FiO2 at admission	0.9985	0.8731–1.1014	0.282
RR at admission	0.9621	0.9274–1.1981	0.118
O2 response	0.5901	0.3644–0.9557	0.032
CO2 response (VR)	0.2537	0.1483–0.4341	< 0.001
PEEP (day 1)	0.9484	0.8414–1.0691	0.388
Death
Age	1.0581	1.0257–1.0915	0.004
Type 2 DM	0.9894	0.5432–1.8019	0.971
ISARIC 4C score	1.0597	0.9427–1.1912	0.334
PP therapy	0.2329	0.1127–0.4813	< 0.001
paO2/FiO2 at admission	0.9862	0.9420–1.2004	0.286
O2 responder	0.6490	0.3679–1.1448	0.137
CO2 responder (VR)	0.2755	0.0486–0.5107	< 0.001
PEEP (day 1)	1.0709	0.9354–1.2261	0.333
Endotracheal intubation^a
PP therapy	0.1938	0.0870–0.4317	< 0.001
pO2/FiO2 at admission	0.9929	0.9873–1.0986	0.132
RR at admission	0.9618	0.9260–1.1096	0.108
O2 responder	0.4623	0.2399–0.8906	0.022
CO2 responder (VR)	0.1991	0.1008–0.3934	< 0.001
PEEP (day 1)	0.9509	0.7196–1.1063	0.164

^aFor those with a full-treatment indication (n = 166)
ISARIC, International Severe Acute Respiratory Infection Consortium; NIV, noninvasive ventilation; SAPS, Simplified acute physiology score
Statistically significant differences are written in bold character

ISSN: 1364-8535