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Fig. 5 | Critical Care

Fig. 5

From: Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study

Fig. 5Fig. 5Fig. 5

Relationship between gas exchange parameters at day 1 and clinical outcomes (NIV failure, death, endotracheal intubation, ETI) (n = 182). A–C Relationship between dead space index Ventilatory Ratio (VR) and NIV failure, death and ETI within each paO2/FiO2 quartile at timepoint sp1 (i.e., supine position at day 1, corresponding in the PP group to resupination after the first 8-h overnight PP session). paO2/FiO2 range within each quartile and PEEP (median, IQR) at which measurements were made are reported at the bottom of the panels. §p < 0.001 versus treatment failure within quartile. D–F Simultaneous impact of O2 response and CO2 response on NIV failure, death and ETI. CO2 response was assessed via ventilatory ratio (VR). *p < 0.05 versus other groups #p < 0.01 versus other groups ¶p < 0.001 versus other groups

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Critical Care

ISSN: 1364-8535