Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis

Aneman, Anders; Frost, Steven; Parr, Michael; Skrifvars, Markus B.

doi:10.1186/s13054-022-03935-z

Critical Care

Table 2 Included randomised controlled studies on targeted temperature management after cardiac arrest

From: Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis

Study	Study setting	Years	Inclusion criteria	Number of patients	Intervention group	Control group	Primary outcome	Intervention group		Control group
Study	Study setting	Years	Inclusion criteria	Number of patients	Intervention group	Control group	Primary outcome	Deaths/total	Unfavourable neurological outcome/total	Deaths/total	Unfavourable neurological outcome/total
Bernard [42]	Single centre in Melbourne, Australia	1996–1999	OHCA, initial rhythm VF, age > 18 (men) and > 50 (women)		TTM at 33 °C for 18 h	No TTM, unclear about fever treatment	Proportion of CPC 1–2 at hospital discharge	22/43	22/43	23/34	25/34
HACA [37]	Multiple centres in Europe	1996–2001	OHCA and some IHCA, shockable rhythm, witnessed, age 18–75	275	TTM at 32–34 °C, for 24 h	No TTM, unclear about fever treatment	Proportion of CPC 1–2 at six months	56/137	61/136	76/138	83/137
Laurent [38]	Single centre in Paris, France	2000–2002	OHCA only, all rhythms, age 18–75	42	TTM at 32–33 °C for 16 h	No TTM, unclear about fever treatment	Survival until six months	15/22	15/22	11/20	11/20
Hachimi-Idrissi [39]	Single centre in Belgium	1999–2002	OHCA only, non-shockable rhythm, age > 18 years	28	TTM at 33 °C for 24 h	No TTM, unclear about fever treatment	Level of s100b	6/14	8/ 14	8/14	11/14
Nielsen [40]	Multiple centres in Europe and Australia	2010–2103	OHCA, all rhythms, age > 18	950	TTM at 33 °C for28h	TTM at 36 °C for 28 h	All-cause mortality until six months	226/473	251/469	220/466	242/464
Lascarrou [41]	Multiple centres in France	2014–2018	OHCA or IHCA, non-shockable rhythm, age > 18	584	TTM at 33 °C for 24 h	TTM at 36.5–37.5 °C	Proportion of CPC 1–2 at 90 days	231/284	255/284	247/297	280/297
Dankiewicz [17]	Multiple centres in Europe, Australia, New Zealand and USA	2017–2020	OHCA, all rhythms, age > 18	1900	TTM at 33 °C for 24 h	TTM, if > 37.8 °C then 37.5 °C	All-cause mortality until six months	465/925	488/881	446/925	479/866

OHCA out-of-hospital cardiac arrest, VF ventricular fibrillation, TTM targeted temperature management, HACA hypothermia after cardiac arrest, IHCA in-hospital cardiac arrest, CPC cerebral performance category

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com