Fig. 1 (abstract P168)

A graphical summary of the future development of the administration of lipophilic lidocaine base in the sublingual region or elsewhere in the oral cavity. We postulate that selective inhibition of the P2X7Rs of the immune cells of the lymphatic system by lidocaine suppresses hyperinflammation in two stages. Stage 1: The selective inhibition of the P2X7Rs of the immune cells residing in the lymph nodes (stage 1a) induces clonal expansion of Tregs with improved function in these lymph nodes (stage 1b); Stage 2: Subsequently, these Tregs migrate throughout the body exerting anti-inflammatory activities reducing systemic and (distant) local hyperinflammation.