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Table 1 Pulmonary, hemodynamic and gas exchange variables at start and end of experiment (series III)

From: Repeated endo-tracheal tube disconnection generates pulmonary edema in a model of volume overload: an experimental study

 

Disconnect (n = 6)

Control (n = 6)

0 min

180 min

0 min

180 min

Plateau pressure (cmH2O)

24.3 ± 1.0

30.6 ± 2.6*Ɨ

25.6 ± 1.7

26.2 ± 1.7

Driving pressure (cmH2O)

9.3 ± 1.0

15.6 ± 2.6*Ɨ

10.6 ± 1.7

11.2 ± 1.7

CRS (mL/cmH2O)

27.6 ± 1.8

17 ± 2.8*Ɨ

25.4 ± 2.8

24.0 ± 2.5

EELV (mL)

3135 ± 354

2021 ± 457Ɨ

3440 ± 625

2395 ± 226Ɨ

Mean FAP (mmHg)

83 ± 6

95 ± 10

90 ± 15.7

100 ± 20

CVP (mmHg)

11.0 ± 4.0

16 ± 5.0

11.0 ± 3.0

14.0 ± 5

Mean PAP (mmHg)

27.5 ± 5.7

32 ± 3.8*Ɨ

26.6 ± 5.2

21.8 ± 2.9Ɨ

PAWP (mmHg)

14.8 ± 1.2

17.4 ± 4.5

13.0 ± 3.1

14.6 ± 2.8

LVEDP (mmHg)

10.7 ± 3.3

17.5 ± 5.0Ɨ

10.5 ± 1.8

14.3 ± 3.7Ɨ

Cardiac output (L/min)

5.2 ± 0.2

5.3 ± 0.4

5.3 ± 0.6

4.9 ± 0.3

PVR (dynes/sec/cm−5)

255.5 ± 78.2

213.3 ± 72.2

247.0 ± 92.7

122.0 ± 88.6Ɨ

pH

7.24 ± 0.04

7.2 ± 0.05

7.24 ± 0.03

7.27 ± 0.04

PaO2 (mmHg)

76.5 ± 6.0

62 ± 12*Ɨ

73 ± 6.1

89 ± 11Ɨ

PaCO2 (mmHg)

59.4 ± 3.7

63 ± 10

62.4 ± 6.0

58 ± 7.0

  1. Pigs with volume overload were ventilated on PEEP 15 cmH2O and then randomized to either receive 15 s ETT disconnects every 15 min (Disconnect group) or no disconnects (Control group); for 3 h. Pulmonary, hemodynamic and gas exchange parameters were compared at start (0 min) and end (180 min) between both groups
  2. ETT endo-tracheal tube, CRS Compliance of the respiratory system, EELV end-expiratory lung volume, FAP femoral arterial pressure, CVP central venous pressure, PAP pulmonary arterial pressure, PAWP pulmonary artery wedge pressure, LVEDP left ventricular end-diastolic pressure
  3. *P < 0.05 t-test Disconnect versus Control; ƗP < 0.05 t-test 0 min versus 180 min
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Critical Care

ISSN: 1364-8535