Skip to main content
Fig. 1 | Critical Care

Fig. 1

From: Repeated endo-tracheal tube disconnection generates pulmonary edema in a model of volume overload: an experimental study

Fig. 1

Hemodynamics and oxygenation during high versus low PEEP deflation (series I). Normal Pigs (n = 6) either received an increase in PEEP from 5 to 26 cmH2O followed by instantaneous deflation to 0 cmH2O (High PEEP group; closed circles) or continuous ventilation at PEEP 5cmH2O and deflation to 0 cmH2O at the same time point (Low PEEP group; open circles). The point of deflation is indicated by the red arrow. In the High PEEP group, increase in PEEP led to a corresponding increase in mean PA (A) with no change in LVEDP (E); at time of deflation the mean PA rose transiently and LVEDP decreased, thereby increasing the TPG (B). This was not observed in the low PEEP group. The cardiac output (D) in high PEEP group decreased with increasing PEEP but returned to the control levels after release of PEEP. PaO2 increased (C) with increasing PEEP and significantly decreased after PEEP removal. At 30 min after deflation PaO2 was similar in both groups. #P < 0.05, post-hoc t test High PEEP versus Low PEEP. Abbreviations: PEEP positive end-expiratory pressure, PA pressure pulmonary artery pressure, TPG transpulmonary gradient, LVEDP left ventricular end-diastolic pressure

Back to article page