Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis

He, Wenhua; Chen, Peng; Lei, Yupeng; Xia, Liang; Liu, Pi; Zhu, Yong; Zeng, Hao; Wu, Yao; Ke, Huajing; Huang, Xin; Cai, Wenhao; Sun, Xin; Huang, Wei; Sutton, Robert; Zhu, Yin; Lu, Nonghua

doi:10.1186/s13054-022-03922-4

Critical Care

Table 3 Intra-abdominal pressure from randomization to 7 days

From: Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis

Time (h)	Intention-to-treat analysis			Subgroup analysis (IAP > 15 mmHg at baseline)			Per-protocol analysis
	Neostigmine (n = 40)	Conventional (n = 40)	P value^†	Neostigmine (n = 25)	Conventional (n = 23)	P value^†	Neostigmine (n = 40)	Conventional (n = 36)	P value^†
	IAP	IAP	P value^†	IAP	IAP	P value^†	IAP	IAP	P value^†
0	16.3 ± 2.7	15.9 ± 2.4		17.9 ± 2.0	17.6 ± 1.7		16.3 ± 2.7	15.9 ± 2.5
3	14.6 ± 3.0	15.0 ± 3.1	0.205	15.0 ± 3.0	16.7 ± 2.6	0.010	14.6 ± 3.0	14.9 ± 2.9	0.322
9	13.8 ± 3.5	15.0 ± 3.1	0.038	14.2 ± 3.3	16.0 ± 3.4	0.018	13.8 ± 3.5	14.7 ± 2.8	0.079
15	13.3 ± 3.4	14.7 ± 3.1	0.015	13.2 ± 3.7	15.8 ± 3.0	0.001	13.3 ± 3.4	14.7 ± 3.1	0.015
24	13.7 ± 3.6	14.7 ± 3.2	0.083	13.7 ± 3.6	15.2 ± 3.2	0.020	13.7 ± 3.6	14.5 ± 3.1	0.152
30	13.7 ± 3.5	14.3 ± 3.1	0.323	13.4 ± 3.2	15.0 ± 2.9	0.038	13.7 ± 3.5	14.0 ± 3.1	0.533
36	14.3 ± 3.6	13.8 ± 3.0	0.619	14.2 ± 3.5	14.1 ± 3.1	0.849	14.3 ± 3.6	13.7 ± 3.0	0.521
42	13.8 ± 3.1	14.2 ± 2.6	0.454	13.7 ± 3.4	14.5 ± 2.4	0.183	13.8 ± 3.1	14.2 ± 2.5	0.465
48	14.1 ± 3.2	13.7 ± 2.9	0.767	14.8 ± 3.0	14.4 ± 2.2	0.895	14.1 ± 3.2	13.4 ± 2.9	0.489
54	13.6 ± 3.4	13.4 ± 2.8	0.961	14.1 ± 3.4	14.0 ± 2.1	0.845	13.6 ± 3.4	13.2 ± 2.6	0.790
60	13.0 ± 3.1	13.6 ± 2.6	0.280	13.0 ± 3.2	14.1 ± 2.1	0.097	13.0 ± 3.1	13.3 ± 2.4	0.522
66	13.6 ± 3.1	13.3 ± 3.9	0.853	14.0 ± 2.8	13.7 ± 3.4	0.904	13.6 ± 3.1	12.9 ± 3.7	0.468
72	13.2 ± 2.9	13.8 ± 2.9	0.237	13.8 ± 3.1	14.2 ± 2.4	0.490	13.2 ± 2.9	13.4 ± 2.6	0.589
120	13.2 ± 3.2	13.8 ± 2.9	0.213	13.6 ± 3.2	14.4 ± 2.8	0.261	13.2 ± 3.2	13.2 ± 2.2	0.731
168	12.2 ± 2.7	13.6 ± 3.5	0.045	11.9 ± 2.8	14.2 ± 3.6	0.013	12.2 ± 2.7	13.0 ± 2.7	0.199

IAP, intra-abdominal pressure
^†IAP at each time point were analyzed as post values in the intervention group versus post values in the control group by ANCOVA

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