Outcome measure | Feeding guideline 48 ICUs, 1399 pts | Control 49 ICU, 1373 pts | Difference (95% CI) | P value | ICC or design effect | |
---|---|---|---|---|---|---|
Feeding guideline | Control | |||||
All-cause mortality at day 28, No (%) | 188 (14.2%) | 205 (15.2%) | − 1.59% [− 4.34%, 1.15%] | 0.42 | 0.11 | 0.05 |
ICU-free days within 28 days, d | 9.1 ± 8.9 | 8.7 ± 8.8 | 0.48 [− 1.02, 1.98] | 0.53 | 0.13 | 0.14 |
Incidence of new infections in ICU, No (%) | 97 (6.9%) | 92 (6.7%) | 0.13% [− 1.87%, 2.13%] | 0.93 | 0.21 | 0.26 |
Adverse events, no./total no. of events | 6 | 11 | Â | 0.47 | Â | Â |
Gastrointestinal events | 4 | 3 | Â | 0.66 | Â | Â |
Others* | 2 | 8 | Â | 0.32 | Â | Â |
Serious adverse events#, no./total no. of patients | 1 | 3 | Â | 0.38 | Â | Â |