Brain Injury Biomarkers for Predicting Outcome After Cardiac Arrest

Humaloja, Jaana; Ashton, Nicholas J.; Skrifvars, Markus B.

doi:10.1186/s13054-022-03913-5

Critical Care

Table 1 Selected studies on the prognostic ability of six brain injury biomarkers after cardiac arrest (CA)

From: Brain Injury Biomarkers for Predicting Outcome After Cardiac Arrest

Biomarker	Study	N	CA location	24-h threshold	48-h threshold	72-h threshold
NSE ng/ml	Zandbergen, 2006 [12]	231	NS	31.7	23.8	32.3
	AUROC			NA	NA	NA
	Sensitivity (%)			NA	NA	NA
	Lee, 2013 [14]	224	NS	80.8	52.7	NA
	AUROC			0.80	0.90
	Sensitivity (%)			27	60
	Larsson, 2014 [15]	125	OHCA/IHCA	49	40	22
	AUROC			0.73	0.79	0.85
	Sensitivity (%)			27	37	50
	Stammet, 2015 [16]	686	OHCA	107	120	50
	AUROC			0.75	0.85	0.86
	Sensitivity (%)			9	27	52
	Helwig, 2017 [17]	100	OHCA	NA	34	NA
	AUROC				0.63
	Sensitivity (%)				44
	Streitberger, 2017 [9]	828	OHCA	NA	NA	85.5
	AUROC					0.90
	sensitivity (%)					49
	Streitberger, 2017 [9]	225	IHCA	NA	NA	1227
	AUROC					0.79
	Sensitivity (%)					0
	Nakstad, 2020 [19]	237	OHCA	172	87	79
	AUROC			NA	NA	NA
	Sensitivity (%)			8	36	39
S100B ng/ml	Larsson, 2014 [15]	125	OHCA + IHCA	1.3	0.61	0.38
	AUROC			0.78	0.75	0.83
	Sensitivity (%)			23	21	30
	Stammet, 2017 [24]	687	OHCA	2.59	3.67	1.83
	AUROC			0.80	NA	NA
	Sensitivity (%)			10	5	5
	Duez, 2018 [23]	115	OHCA	1.05	0.95	0.72
	AUROC			0.81	0.81	0.74
	Sensitivity (%)			23	17	11
	Jang, 2019 [22]	97	OHCA	0.19	0.16	0.20
	AUROC			0.93	0.92	0.86
	Sensitivity (%)			78	78	61
NfL pg/ml	Rana, 2013 [26]	61	OHCA	321	405	309
	AUROC			0.93	0.85	0.92
	Sensitivity (%)			79	57	75
	Moseby-Knappe, 2019 [5]	717	OHCA	1232	1539	1756
	AUROC			0.94	0.94	0.94
	Sensitivity (%)			53	65	64
	Wihersaari, 2021 [4]	112	OHCA	150	359	390
	AUROC			0.98	0.99	0.98
	Sensitivity (%)			78	83	85
UCH-L1 pg/ ml	Ebner, 2020 [36]	717	OHCA	12,175	7945	9170
	AUROC			0.85	0.87	0.86
	Sensitivity (%)			4	9	1
GFAP pg/ml	Larsson, 2014 [15]	125	OHCA + IHCA	1090	300	530
	AUROC			0.59	0.63	0.67
	Sensitivity (%)			16	23	14
	Helwig, 2017 [17]	100	OHCA	NA	80	NA
	AUROC				0.65
	Sensitivity (%)				21
	Ebner, 2020 [36]	717	OHCA	3425	2952	3581
	AUROC			0.88	0.88	0.89
	Sensitivity (%)			17	19	12
Tau pg/ml	Mattsson, 2017 [48]	689	OHCA	874.5	148.8	72.7
	AUROC			0.81	0.90	0.91
	Sensitivity (%)			4	33	42

AUROC area under the receiver operating characteristic curve, CA cardiac arrest, NA not applicable, NS not specified, OHCA out-of-hospital cardiac arrest, IHCA in-hospital cardiac arrest, Nfl neurofilament light protein, S100B S100 calcium-binding protein B, GFAP glial fibrillary acidic protein, UCH-L1 ubiquitin C-terminal hydrolase L1

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com