From: Immunomodulation by Tetracyclines in the Critically Ill: An Emerging Treatment Option?
Author | Year | Tetracycline | Model | Stimulants or pathogens | Immune response |
---|---|---|---|---|---|
Peukert et al. [5] | 2021 | Tetracycline | Mouse, human (ex vivo) | LPS, H1N1 influenza virus (mouse); viral, bacterial, and non-pulmonary ARDS (human) | IL-1ß, IL-18, caspase-1 activation, neutrophil influx ↓, survival ↑ |
Zhang et al. [20] | 2019 | Doxycycline | Mouse | Paraquat | MMP-9, MPO, neutrophil influx ↓ |
Wang et al. [24] | 2014 | Doxycycline | Rat | Cardiopulmonary bypass | TNF-α, IL-1ß, MMP-9 ↓ |
Zhang et al. [17] | 2014 | Doxycycline | Dog | Cardiopulmonary bypass | MMP-9, MPO, neutrophil influx ↓ |
Roy et al. [16] | 2012 | CMT-3 | Pig | Ischemia by clamping of SMA, placement of fecal clot in peritoneum | TNF-α, IL-1ß, IL-6, IL-8, IL-10 ↓, MMP-2, -9, NE, survival ↔ |
Ng et al. [27] | 2012 | Doxycycline | Mouse | H3N2 influenza virus | MMP-2, MMP-9, T1-α, thrombomodulin, neutrophil influx ↓ |
Moon et al. [22] | 2012 | Doxycycline | Mouse | LPS | Syndecan-1 (MMP-7 substrate), neutrophil influx ↓ |
Zhou et al. [25] | 2010 | CMT-3 | Sheep | 3rd degree burn, smoke inhalation, barotrauma | MMP-2 ↓, MMP-9 ↔, survival ↑ |
Sochor et al. [21] | 2009 | Doxycycline | Rat | Acute pancreatitis (intraductal glycodeoxycholic acid, cerulein) | MMP-9, neutrophil influx ↓ |
Fujita et al. [26] | 2007 | Doxycycline | Mouse | LPS or Streptococcus pneumoniae | MMP-2, -9, neutrophil influx ↓, survival ↑ |
Kim et al. [14] | 2006 | CMT-3 | Rat | Ventilation | MMP-9, MPO, neutrophil influx ↓ |
Fujita et al. [28] | 2006 | Doxycycline | Mouse | Bleomycin | MMP-2, -9, neutrophil influx ↓ |
Steinberg et al. [19] | 2005 | CMT-3 | Pig | Ischemia by clamping of SMA, placement of fecal clot in peritoneum | IL-6, IL-8, IL-10, NE ↓, IL-1, MMP-2, -9, neutrophil influx ↔, survival ↑ |
Steinberg et al. [15] | 2003 | CMT-3 | Rat | Cecal ligation and puncture | MMP-2, MMP-9 ↓, survival ↑ |
Carney et al. [23] | 2001 | CMT-3 | Pig | LPS | MMP-2, MMP-9, neutrophil influx ↓ |
McCann et al. [29] | 1999 | CMT-3 | Pig | Cardiopulmonary bypass, LPS | Neutrophil influx ↓ |
Carney et al. [13] | 1999 | CMT-3 | Pig | Cardiopulmonary bypass, LPS | MMP-2, MMP-9, NE, neutrophil influx ↓, survival ↑ |