Table 3 Univariate comparison of potential risk factors for CAPA in cases and controls

Parameters on admission

Age (years)

65.5 (IQR 55.5–75.1)

67.4 (IQR 62.4–75.9)

0.105

Male gender

75% (n = 126)

87% (n = 41)

0.075

BMI (kg/m²)

29 (IQR 25.5–32)

30 (IQR 26–34)

0.499

SAPS

41 (IQR 32–48)

51 (IQR 44–59)

 < 0.001

Lymphcytes/nl

0.83 (IQR 0.56–1.22)

0.77 (IQR 0.38–1.06)

0.112

Neutrophils/nl

7.94 (IQR 5.51–11.13)

8.14 (IQR 5.55–11.94)

0.781

IL-6 (ng/l)

110 (IQR 34.3–315.4)

91.65 (IQR 58.3–215)

0.868

CRP (mg/l)

142.3 (IQR 68.9–234.3)

160.8 (IQR 108.6–270.9)

0.167

PCT (µg/l)

0.38 (IQR 0.15–1.49)

0.71 (IQR 0.22–2)

0.169

Corticosteroids on admission

8% (n = 10)

21% (n = 24)

 < 0.001

Admission from external ICU

42% (n = 71)

21% (n = 24)

0.283

ICU treatment parameters

Number of microbiological samples for Aspergillus spp.

3 (IQR 0–7)

7 (IQR 5–11)

0.000

Length of ICU stay before onset of CAPA (days)

Not applicable

8 (IQR 4–14)

Not applicable

Dexamethasone therapy

76.2% (n = 128)

87.2% (n = 41)

0.103

Cortisol cumulative dose (mg)

1.470 (390–2.670)

900 (200–2.200)

0.154

Corticosteroid treatment (days)

7 (IQR 2–12)

6 (IQR 2–10)

0.298

Invasive ventilation (days)

12 (IQR 1–32)

23 (IQR 16–38)

 < 0.001

Days without mechanical ventilation

1 (IQR 0–6)

1 (IQR 0–5)

0.171

Comorbidities

Charlson Comorbidity Index

5 (IQR 3–7)

6 (IQR 5–8)

0.015

Peptic ulcer

2% (n = 4)

4% (n = 2)

0.490

Rheumatoid disease

4% (n = 7)

4% (n = 2)

0.979

Heart disease

24% (n = 41)

15% (n = 7)

0.166

Vascular disease

15% (n = 25)

17% (n = 8)

0.719

Diabetes

31% (52)

32% (n = 15)

0.900

Liver disease

20% (n = 33)

23% (n = 11)

0.572

Renal disease

65% (n = 109)

87% (n = 41)

0.003

Cancer

5% (n = 9)

11% (n = 5)

0.195

AIDS/HIV

0 (n = 0)

0 (n = 0)

n.s

Neurological disease

8% (n = 14)

6% (n = 3)

0.661

Lung disease

29% (n = 49)

40% (n = 19)

0.142