Table 2 Baseline characteristics of patients stratified by timing of surgical
Variable | No. of patients with complete data | All patients (N = 1595) | Timing of surgical source control | ||
|---|---|---|---|---|---|
Whithin 6 h (N = 924) | More than 6 h (N = 671) | p value | |||
Time to surgical source control (minutes) | 1595 | 275 [81, 810] | 109 [38, 225] | 950 [593, 1500] | – |
Age | 1595 | 70 [59, 77] | 70 [60, 78] | 69 [59, 76] | 0.152 |
Sex: male | 1595 | 934 (58.6%) | 538 (58.2%) | 396 (59%) | 0.758 |
Origin of infection: Community acquired | 1595 | 795 (49.8%) | 507 (54.9%) | 288 (42.9%) | ≤ 0.001 |
Nosocomial (ICU/IMC) | 292 (18.3%) | 111 (12%) | 181 (27%) | ||
Nosocomial (general ward) | 508 (31.8%) | 306 (33.1%) | 202 (30.1%) | ||
Location at onset of sepsis: ICU | 1595 | 573 (35.9%) | 255 (27.6%) | 318 (47.4%) | ≤ 0.001 |
Emergency department | 298 (18.7%) | 170 (18.4%) | 128 (19.1%) | ||
Operating room | 344 (21.6%) | 324 (35.1%) | 20 (3%) | ||
General ward | 232 (14.5%) | 107 (11.6%) | 125 (18.6%) | ||
Ambulance service | 39 (2.4%) | 22 (2.4%) | 17 (2.5%) | ||
IMC | 109 (6.8%) | 46 (5%) | 63 (9.4%) | ||
Focus of infection: respiratory | 1595 | 171 (10.7%) | 69 (7.5%) | 102 (15.2%) | ≤ 0.001 |
Focus of infection: abdominal | 1595 | 1161 (72.8%) | 705 (76.3%) | 456 (68%) | ≤ 0.001 |
Focus of infection: urogenital | 1595 | 121 (7.6%) | 60 (6.5%) | 61 (9.1%) | 0.056 |
Focus of infection: bones/soft tissue/wound | 1595 | 272 (17.1%) | 135 (14.6%) | 137 (20.4%) | 0.003 |
Focus of infection: other/unknown | 1595 | 117 (7.3%) | 59 (6.4%) | 58 (8.6%) | 0.098 |
Infection microbiologically confirmed | 1592 | 1239 (77.8%) | 696 (75.6%) | 543 (80.9%) | 0.012 |
Bacteremia: gram positive | 1587 | 224 (14.1%) | 99 (10.8%) | 125 (18.7%) | ≤ 0.001 |
Gram negative | 206 (13%) | 117 (12.7%) | 89 (13.3%) | ||
Other/several | 54 (3.4%) | 29 (3.2%) | 25 (3.7%) | ||
No pathogen detected | 720 (45.4%) | 421 (45.9%) | 299 (44.7%) | ||
No blood culture taken | 383 (24.1%) | 252 (27.5%) | 131 (19.6%) | ||
Vasopressor use within 12 h after first organ dysfunction | 1590 | 1346 (84.7%) | 830 (90.2%) | 516 (77%) | ≤ 0.001 |