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Table 4 The hospital stratified multivariate Cox proportional-hazards regression analysis to identify variables significantly and independently associated with 28-day mortality (A) and hospital mortality rates (B)

From: Relationship between time of emergency department admission and adherence to the Surviving Sepsis Campaign bundle in patients with septic shock

Variable

28-day mortality

HR (95% CI)

P

HR (95% CI)

P

(A)

Age

1.004 (0.996–1.012)

0.344

1.003 (0.995–1.011)

0.412

Male sex

1.030 (0.835–1.271)

0.781

1.037 (0.840–1.279)

0.737

APACHE II score

1.088 (1.075–1.101)

 < 0.001*

1.087 (1.074–1.100)

 < 0.001*

Lactate

1.105 (1.078–1.132)

 < 0.001*

1.103 (1.076–1.130)

 < 0.001*

C-reactive protein

1.004 (0.996–1.012)

0.357

1.004 (0.996–1.012)

0.351

Patients/doctor ratio

0.999 (0.999–1.000)

0.679

0.100 (0.999–1.000)

0.759

Source of infection

 Hepato-biliary and pancreas

0.793 (0.567–1.110)

0.177

0.785 (0.561–1.098)

0.157

 Mixed source

1.146 (0.838–1.566)

0.394

1.139 (0.834–1.556)

0.413

Respiratory tract

1.288 (0.995–1.668)

0.055

1.236 (0.956–1.597)

0.106

 Urinary tract

0.454 (0.309–0.667)

 < 0.001*

0.453 (0.308–0.664)

 < 0.001*

Timely antibiotic administration

0.742 (0.600–0.916)

0.006*

  

Adherence of complete SSC bundle

  

0.750 (0.590–0.952)

0.018*

Variable

Hospital mortality

HR (95% CI)

P

HR (95% CI)

P

(B)

Age

1.003 (0.996–1.011)

0.408

1.003 (0.995–1.010)

0.504

Male sex

0.978 (0.799–1.198)

0.831

0.982 (0.802–1.202)

0.860

APACHE II score

1.092 (1.079–1.106)

 < 0.001*

1.091 (1.078–1.105)

 < 0.001*

Lactate

1.104 (1.078–1.131)

 < 0.001*

1.103 (1.077–1.130)

 < 0.001*

C-reactive protein

1.005 (0.997–1.012)

0.205

1.005 (0.997–1.012)

0.220

Patients/doctor ratio

0.999 (0.999–1.000)

0.442

0.100 (0.999–1.000)

0.503

Source of infection

 Hepato-biliary and pancreas

0.750 (0.538–1.045)

0.089

0.743 (0.533–1.035)

0.079

 Mixed source

1.074 (0.790–1.460)

0.648

1.073 (0.790–1.457)

0.653

 Respiratory tract

1.285 (1.002–1.649)

0.049*

1.235 (0.964–1.582)

0.095

 Urinary tract

0.394 (0.269–0.576)

< 0.001*

0.393 (0.268–0.574)

< 0.001*

Timely antibiotic administration

0.738 (0.600–0.908)

0.004*

  

Adherence of complete SSC bundle

  

0.714 (0.564–0.904)

0.005*

  1. HR hazard ratio, 95% CI 95% confidence interval, APACHE Acute Physiologic Assessment and Chronic Health Evaluation, SSC Surviving Sepsis Campaign
  2. *P < 0.05