Table 3 Clinical and hemodynamic parameters at admission and 1 h after vitamin C infusion of included patients according to vitamin C deficiency
From: Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients
Variables, median (IQR) | H0 | H1 | p value (H1 vs H0) | |||
|---|---|---|---|---|---|---|
Vitamin C (µmol/L) | < 5 µmol/L | ≥ 5 µmol/L | < 5 µmol/L | ≥ 5 µmol/L | < 5 µmol/L | ≥ 5 µmol/L |
Blood pressure (mmHg) | ||||||
Systolic | 103 [100–115] | 108 [101–122] | 109 [96–124] | 110 [101–120] | 0.26 | 0.8 |
Diastolic | 56 [53–64] | 53 [45–59] | 58 [52–63] | 56 [51–62] | 0.9 | 0.11 |
Mean | 71 [66–77] | 67 [61–71] | 74 [67–79] | 68 [64–75] | 0.29 | 0.05 |
Heart rate (/min) | 105 [100–111] | 107 [101–124] | 105 [100–110] | 107 [100–124] | 0.8 | 0.9 |
Mottling score | 1 [0–3] | 2 [0–3] | 1 [0–2] | 2 [0–3] | 0.6 | 0.9 |
Capillary refill time (s) | ||||||
Index | 1.8 [1.6–3.9] | 2.2 [1.6–3.1] | 1.7 [1.2–3.5] | 1.9 [1.1–2.7] | 0.04 | 0.02 |
Knee | 3.8 [2.5–5.8] | 4.1 [3.4–6] | 2.7 [1.9–4.7] | 3.5 [2.3–5.6] | 0.001 | 0.005 |
Cardiac output (L/min) | 3.3 [3–4.2] | 4.3 [3.8–5.2] | 3.5 [3.1–4.2] | 4.3 [3–4.7] | 0.5 | 0.04 |
Temperature (°C) | ||||||
Skin | 31.7 [30.2–32.7] | 31.2 [30.5–32.8] | 32 [31.1–34.3] | 32.2 [31.2–33.6] | 0.06 | 0.008 |
Central-to-skin gradient | 6.5 [4.8–7.3] | 5.3 [4.7–6.8] | 4.9 [3.5–6.9] | 4.5 [3.3–6.6] | 0.06 | 0.001 |
Norepinephrine infusion (µg/kg min) | 0.6 [0.2–0.7] | 1.1 [0.4–1.4] | 0.6 [0.2–0.7] | 1.0 [0.4–1.4] | 0.9 | 0.5 |