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Table 3 Clinical and hemodynamic parameters at admission and 1 h after vitamin C infusion of included patients according to vitamin C deficiency

From: Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients

Variables, median (IQR) H0 H1 p value (H1 vs H0)
Vitamin C (µmol/L) < 5 µmol/L ≥ 5 µmol/L < 5 µmol/L ≥ 5 µmol/L < 5 µmol/L ≥ 5 µmol/L
Blood pressure (mmHg)
Systolic 103 [100–115] 108 [101–122] 109 [96–124] 110 [101–120] 0.26 0.8
Diastolic 56 [53–64] 53 [45–59] 58 [52–63] 56 [51–62] 0.9 0.11
Mean 71 [66–77] 67 [61–71] 74 [67–79] 68 [64–75] 0.29 0.05
Heart rate (/min) 105 [100–111] 107 [101–124] 105 [100–110] 107 [100–124] 0.8 0.9
Mottling score 1 [0–3] 2 [0–3] 1 [0–2] 2 [0–3] 0.6 0.9
Capillary refill time (s)
Index 1.8 [1.6–3.9] 2.2 [1.6–3.1] 1.7 [1.2–3.5] 1.9 [1.1–2.7] 0.04 0.02
Knee 3.8 [2.5–5.8] 4.1 [3.4–6] 2.7 [1.9–4.7] 3.5 [2.3–5.6] 0.001 0.005
Cardiac output (L/min) 3.3 [3–4.2] 4.3 [3.8–5.2] 3.5 [3.1–4.2] 4.3 [3–4.7] 0.5 0.04
Temperature (°C)
Skin 31.7 [30.2–32.7] 31.2 [30.5–32.8] 32 [31.1–34.3] 32.2 [31.2–33.6] 0.06 0.008
Central-to-skin gradient 6.5 [4.8–7.3] 5.3 [4.7–6.8] 4.9 [3.5–6.9] 4.5 [3.3–6.6] 0.06 0.001
Norepinephrine infusion (µg/kg min) 0.6 [0.2–0.7] 1.1 [0.4–1.4] 0.6 [0.2–0.7] 1.0 [0.4–1.4] 0.9 0.5
  1. Bold was used when p value was ≤ 0.05