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Table 5 ROC analyses for diagnosis of sepsis + DIC according to baseline PC biomarker concentration

From: The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis

Study Diagnostic outcome AUC (95% CI) Cutoff (%) Sn Sp PPV NPV LR+ LR−
Walborn [35] Sepsis + DIC
Masuda [27] Sepsis + DIC 0.86 (0.82–0.90) 42 0.8 0.77 0.6 0.91 3.51 0.26
Koyama [36] Sepsis + DIC 0.85 (0.76–0.91) 46 0.81 0.79 0.79 0.82 3.86 0.24
Chornenki28 Sepsis + Pre-DIC 0.67 (0.58–0.73) 51
  1. AUC area under curve, Sn sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR− negative likelihood ratio