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Table 5 ROC analyses for diagnosis of sepsis + DIC according to baseline PC biomarker concentration

From: The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis

Study

Diagnostic outcome

AUC (95% CI)

Cutoff (%)

Sn

Sp

PPV

NPV

LR+

LR−

Walborn [35]

Sepsis + DIC

–

–

–

–

–

–

–

–

Masuda [27]

Sepsis + DIC

0.86 (0.82–0.90)

42

0.8

0.77

0.6

0.91

3.51

0.26

Koyama [36]

Sepsis + DIC

0.85 (0.76–0.91)

46

0.81

0.79

0.79

0.82

3.86

0.24

Chornenki28

Sepsis + Pre-DIC

0.67 (0.58–0.73)

51

–

–

–

–

–

–

  1. AUC area under curve, Sn sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR− negative likelihood ratio
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Critical Care

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