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Table 4 ROC analyses for prediction of sepsis-related mortality according to baseline protein C biomarker concentration

From: The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis

Study Mortality outcome AUC (95% CI) Cutoff (%) Sn Sp PPV NPV LR+ LR−
Dwivedi [31] ICU 0.57 (0.43–0.70) 66 0.66 0.64
Karamarkovic [38] Mortality 0.92 66 0.8 0.875 0.67 0.94 6.4 0.23
Koyama [36] 28-day 0.64 (0.45–0.79) 37 0.53 0.75 0.35 0.87 2.12 0.63
Liaw [33] 28-day
Mihajlovic [30] 28-day 0.65
Lorente [34] 28-day
Umemura [32] 28-day 0. 85 (0.74–0.96)
Walborn [35] 28-day 0.71
  1. AUC area under curve, Sn sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR− negative likelihood ratio