Table 4 ROC analyses for prediction of sepsis-related mortality according to baseline protein C biomarker concentration
Study | Mortality outcome | AUC (95% CI) | Cutoff (%) | Sn | Sp | PPV | NPV | LR+ | LR− |
|---|---|---|---|---|---|---|---|---|---|
Dwivedi [31] | ICU | 0.57 (0.43–0.70) | 66 | – | – | 0.66 | 0.64 | – | – |
Karamarkovic [38] | Mortality | 0.92 | 66 | 0.8 | 0.875 | 0.67 | 0.94 | 6.4 | 0.23 |
Koyama [36] | 28-day | 0.64 (0.45–0.79) | 37 | 0.53 | 0.75 | 0.35 | 0.87 | 2.12 | 0.63 |
Liaw [33] | 28-day | – | – | – | – | – | – | – | – |
Mihajlovic [30] | 28-day | 0.65 | – | – | – | – | – | – | – |
Lorente [34] | 28-day | – | – | – | – | – | – | – | – |
Umemura [32] | 28-day | 0. 85 (0.74–0.96) | – | – | – | – | – | – | – |
Walborn [35] | 28-day | 0.71 | – | – | – | – | – | – | – |