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Table 1 PICOS criteria for included studies

From: The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis

Parameter Inclusion criteria
Population Adult (> 17 years of age), with sepsis (including severe sepsis, septic shock or sepsis with DIC) or suspicion of sepsis
Intervention Measurement of PC in the blood within 24 h of study enrollment
Comparator N/A
Outcomes Prognostic outcomes: (1) PC biomarker levels in survivors vs. non-survivors and (2) the prognostic accuracy of protein C for sepsis-related mortality
Diagnostic outcomes: (1) PC biomarker levels in septic vs. non-septic patients; (2) the diagnostic accuracy of protein C for sepsis; (3) PC biomarker levels in septic patients with and without DIC; and (4) the diagnostic accuracy of PC for sepsis-induced DIC
Study Design Prospective observational studies