Table 2 Respiratory support strategies
Early IMV | Delayed IMV | p value | N | |
|---|---|---|---|---|
n = 140 Median [IQR] or n (%) | n = 65 Median [IQR] or n (%) | |||
Initial ventilatory support | ||||
Ventilation start site | < 0.001 | 205 | ||
General ward | 31 (22.1%) | 33 (50.8%) | ||
ICU | 109 (77.9%) | 32 (49.2%) | ||
Time from hospital admission to initial ventilatory support (days) | 0.00 [0.00; 1.00] | 0.00 [0.00; 1.00] | 0.019 | 205 |
PaO2 to FiO2 ratio | 98.8 [70.0; 132] | 129 [100; 150] | < 0.001 | 183 |
Respiratory rate | 30.0 [24.0; 36.0] | 24.0 [20.0; 27.8] | < 0.001 | 171 |
Respiratory support management prior to intubation | < 0.001 | 205 | ||
None | 28 (20.0%) | 0 (0.00%) | ||
High-flow nasal cannula | 39 (27.9%) | 2 (3.08%) | ||
CPAP/BIPAP | 29 (20.7%) | 3 (4.62%) | ||
Both therapies | 44 (31.4%) | 60 (92.3%) | ||
ROX index | 3.55 [2.26; 5.43] | 5.70 [4.45; 7.33] | < 0.001 | 140 |
IMV | ||||
Time from hospitalization to IMV (days) | 1.00 [0.00; 2.00] | 5.00 [4.00; 7.00] | < 0.001 | 205 |
Time from initial ventilatory support to IMV (days) | 1.00 [0.00; 1.00] | 4.00 [3.00; 6.00] | < 0.001 | 205 |
PaO2 to FiO2 ratio | 74.0 [61.2; 99.0] | 74.0 [60.0; 91.0] | 0.560 | 195 |
Respiratory rate | 29.0 [22.0; 35.0] | 25.0 [22.0; 30.0] | 0.019 | 148 |
Duration (days) | 13.0 [7.00; 24.0] | 17.0 [7.75; 30.0] | 0.431 | 202 |
Prone positioning | 106 (75.7%) | 53 (81.5%) | 0.453 | 205 |
Ventilatory setting and pulmonary mechanics | ||||
Tidal volume/PBW (mL/Kg) | 5.32 [4.66; 6.09] | 5.42 [4.87; 6.05] | 0.665 | 158 |
PEEP, cmH2O | 14 [12; 15] | 13 [12; 14] | 0.421 | 168 |
Peak inspiratory pressure, cmH2O | 34 [30; 37] | 32 [29; 36] | 0.233 | 163 |
End-inspiratory plateau pressure, cmH2O | 25 [22; 29] | 24.5 [19; 28] | 0.261 | 145 |
Driving pressure, cmH2Oa | 12 [8; 14] | 10.5 [6.75; 14] | 0.358 | 145 |
Compliance, mL/cmH2Ob | 39.2 [32; 57] | 45.5 [35; 74] | 0.232 | 142 |